“Exercise Training in Adverse Cardiac Remodeling”
Professor
of
Experimental
Cardiology
at
Erasmus
University,
Netherlands
[Poster]
[Video]
Abstract:
Cardiac
remodeling
in
response
to
a
myocardial
infarction
or
chronic
pressure-overload
is
an
independent
risk
factor
for
the
development
of
heart
failure.
In
contrast,
cardiac
remodeling
produced
by
regular
physical
exercise
is
associated
with
a
decreased
risk
for
heart
failure.
There
is
evidence
that
exercise
training
has
a
beneficial
effect
on
disease
progression
and
survival
in
patients
with
cardiac
remodeling
and
dysfunction,
but
concern
has
also
been
expressed
that
exercise
training
may
aggravate
pathological
remodeling
and
dysfunction.
In
my
talk
I
will
present
the
results
of
studies
from
our
laboratory
investigating
the
effects
of
exercise
training
on
pathological
cardiac
remodeling
and
dysfunction
in
mice,
and
the
mechanisms
underlying
the
divergent
effects
of
physical
exercise
training
in
different
pathologies.
Biosketch:
Dirk
J.
Duncker
obtained
his
PhD
and
MD
degrees,
respectively,
in
1988
and
1989
at
the
Erasmus
University
Rotterdam.
He
worked
as
a
post-doctorate
research
fellow
at
the
University
of
Minnesota
from
1991-1994,
after
which
he
returned
to
the
Department
of
Cardiology
(Thoraxcenter)
of
the
Erasmus
University
Medical
Center
in
Rotterdam.
In
1995
he
received
a
5
year
Research
Fellowship
Stipend
from
the
Royal
Netherlands
Academy
of
Arts
&
Sciences,
and
in
2000
he
became
Established
Investigator
of
the
Netherlands
Heart
Foundation.
He
was
appointed
Professor
of
Experimental
Cardiology
in
2003.
His
research
interests
include
the
regulation
of
coronary
blood
flow
and
microvascular
tone
in
health
and
disease,
pathophysiology
of
cardiac
hypertrophy
and
heart
failure,
and
the
cardiovascular
effects
of
physical
exercise.
If you are interested in meeting with Dr. Duncker, please email Bernie Duncker.
Pay
parking
available
in
lots
B
or
N
(map)
Event
is
FREE
and
coffee/cookies
will
be
available.