Organic Chemistry
Room: ESC 338
Extension: 84642
Email: dmitrien@uwaterloo.ca
Website: Gary Dmitrienko
Education
- Honours BSc in Chemistry (University of Toronto) 1970
- PhD in Organic Chemistry (National Research Council Canada (NRC) Scholarship) (University of Toronto) 1974
- National Research Council Canada (NRC) Postdoctoral Fellow - total synthesis of complex diterpenoid alkaloids (with K. Wiesner, University of of New Brunswick) 1974-75
- NRC Postdoctoral Fellow – enzyme mechanism and inhibition (with V. Snieckus and T. Viswanatha, University of Waterloo), 1975-77
- NRC Industrial Postdoctoral Fellow – medicinal chemistry (Merck-Frosst Centre for Therapeutic Research), 1977-78
Research
- Synthesis of heterocyclic and carbocyclic compounds
- Mechanistic organic chemistry
- Bioorganic and medicinal chemistry related to antimicrobial and anticancer agents
Recent publications
- Cyclobutanone Analogues of b-Lactams Revisited: Insights Into Conformational Requirements for Inhibition of Serine- and Metallo-b-Lactamases, Johnson, J. W.; Gretes, M.; Goodfellow, V. J.; Marrone, L.; Heynen, M. L.; Strynadka, N. C. J.; Dmitrienko, G. I.J. Am. Chem. Soc. 2010, 132, 2558–2560.
- Cyclobutanone Mimics of Penicillins: Effects of Substitution on Conformation and Hemiketal Stability, Johnson, J. W.; Evanoff, D. P.; Savard, M. E.; Lange, G.; Ramadhar, T. R.; Assoud, A.; Taylor, N. J.; Dmitrienko, G. I.J. Org. Chem. 2008, 73, 6970–6982.
- A Biogenetically-Inspired Synthesis of a Ring-D Model of Kinamycin F: Insights Into the Conformation of Ring D, Chen, N.; Carriere, M. B.; Laufer, R. S.; Taylor, N. J.; Dmitrienko, G. I. Org. Lett. 2008, 10, 381–384.
- Structural Studies of the Final Enzyme in the a-Aminoadipate Pathway – Saccharopine Dehydrogenase from Saccharomyces cerevisiae, Burk, D. L.; Hwang, J.; Kwok, E.; Marrone, L.; Goodfellow, V.; Dmitrienko, G. I.; Berghuis, A. M. J. Mol. Biol. 2007, 373, 745–754.
- Mechanism of the Cytotoxicity of the Diazoparaquinone Antitumor Antibiotic Kinamycin, F O’Hara, K. A.; Wu, X.; Patel, D.; Liang, H.; Yalowich, J. C.; Chen, N.; Goodfellow, V.; Adedayo, O.; Dmitrienko, G. I.; Hasinoff, B. B. Free Radic. Biol. Med. 2007, 43, 1132–1144.
