John Honek

Biochemistry

Room: ESC 246

Chair's office extension: 34763

Research office extension: 35817

Email: jhonek@uwaterloo.ca

Website: John Honek

Research

Our interest is to understand the fundamental interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions. Research in this area includes mechanistic enzymology, recombinant DNA and biophysical methods as well as organic synthesis, medicinal chemistry and molecular modeling. An additional focus is in the area of bionanotechnology and the application of biological chemistry to the synthesis of new nanomaterials and nanostructures.

Recent publications

• J. F. Honek, 2013, Aeruginolysin in Handbook of Proteolytic Enzymes 3rd Edition. Rawlings, N. D. and Salvesen, G. Eds., Elsevier Limited, 867-872.

• M. Palmer, A. Chan, T. Dieckmann and J. Honek, (2012) Biochemical Pharmacology, Wiley-VCH.

• K. Y. Mullings, N. Sukdeo, U. Suttisansanee, Y. Ran, and J. F. Honek, 2012, Ni2+-Activated Glyoxalase I from Escherichia coli: Substrate Specificity, Kinetic Isotope Effects and Evolution Within the βαβββ Superfamily. Journal of Inorganic Biochemistry, 108, 133-140.

• U. Suttisansanee, K. Lau, S. Lagishetty, K. N. Rao, S. Swaminathan, J. M. Sauder, S. K. Burley and J. F. Honek, 2011, Structural Variation in Bacterial Glyoxalase I Enzymes: Investigation of the Metalloenzyme Glyoxalase I from Clostridium acetobutylicum. Journal of Biological Chemistry, 286, 38367-38374.

• D. Pradhan, Z. Su, S. Sindhwani, J. Honek and K. T. Leung, 2011, Electrochemical Growth of ZnO Nanobelt-Like Structures at 0 ^oC: Synthesis, Characterization, and in-situ Glucose Oxidase Embedment. Journal of Physical Chemistry C, 115, 18149-18156.