@inproceedings {295,
	title = {Evaluation of hypoxic swelling of human cornea with high speed ultrahigh resolution optical coherence tomography},
	booktitle = {SPIE BIOS (Biomedical Optics)},
	year = {2009},
	month = {01/2009},
	publisher = {SPIE},
	organization = {SPIE},
	address = {San Jose, CA, USA},
	abstract = {<p>Hypoxia induced corneal swelling was observed and evaluated in healthy human volunteers by use of high speed, ultrahigh resolution optical coherence tomography (UHROCT). Two dimensional corneal images were acquired at a speed of 47,000 A-scans/s with 3m x 10m (axial x lateral) resolution in corneal tissue. The UHROCT tomograms showed clear visualization of all corneal layers, including the Bowman\&$\#$39;s layer and the Descemet\&$\#$39;s membrane - Endothelium complex. A segmentation algorithm was developed and used for automatic detection of the boundaries of the different corneal layers and evaluation the individual layer thickness as a function of location. Corneal hypoxia was induced by wear of a soft contact lens (SCL) and an eye patch by 2 healthy volunteers for duration of 3 hours. The thickness of all corneal layers was measured as a function of time, prior to, with and after removal of the SCL. Results from the hypoxia study showed different rates of swelling and de-swelling of the individual corneal layers. About 10\% increase in the total cornea thickness was observed, similar to the changes in the stroma, the Bowman\&$\#$39;s membrane swelled by 20\%, while no significant change in the thickness was observed in the Descemet\&$\#$39;s - Endothelium complex.</p>
},
	doi = {http://dx.doi.org/10.1117/12.809431},
	url = {http://link.aip.org/link/?PSI/7163/71631G/1},
	author = {K Bizheva and C Hyun and J A. Eichel and S Hariri and D A. Clausi and P Fieguth and T Simpson and N Hutchings}
}
