Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
MC 5136
Abhyudai Singh, Department of Electrical & Computer Engineering, University of Delaware
Stochastic Inference of Regulatory Networks Inside Living Cells
In the noisy cellular environment many mRNA and protein species occur at low integer molecular counts, and hence are subject to large stochastic fluctuations in copy numbers over time. Far from being a hindrance, signatures of protein/mRNA noise levels can be informative about the underlying gene network topology. In this talk, I will present recently developed mathematical techniques that harness fluctuations in the levels of biochemical species for systems identification of gene regulatory networks. Finally, I describe our current efforts in using these techniques for reverse engineering the genetic circuitry of the human immunodeficiency virus (HIV).
Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.