Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Research Interests:
Viral vector drug delivery
Biological nano-particles (Virus-Like Particles or VLPs)
Vaccines, gene therapy, gene expression, genetic diseases
Baculovirus Bioprocessing
Process dynamics of virus-based systems for the production of complex biologics such as viral vectors and vaccines
Development of strategies using multiple viruses to obtain recombinant products in cell culture
[YouTube Lecture] September 30, 2014 "Tools and strategies for complex biologics production in animal cells: applications to insect and mammalian cell culture"
[YouTube] January 26, 2011 "Research Profile: Marc Aucoin"
CBB Founder and NSERC CREATE program lead
Research Interests:
[Office of Research] May 22, 2018, CBB Executive Director reappointed for third term
[YouTube] February 5, 2010 "Research Profile: Catherine Burns"
Research Interests:
Nano-Biomedical engineering, biochemistry, molecular cell biology
Colloid and Surface Science (surface chemistry, absorption kinetics, thermodynamics)
Polymer materials, CO2
Energy storage and conversion, battery systems and alternative energy
Drug and gene delivery, genomics
Lipid bilayer and cell membrane actions
University Research Chair
Research Interests:
drug metabolism
pharmacogenomics
drug interactions
bioavailability/bioequivalence
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Intelligent drug delivery system design (dermal, transdermal, transmucosal, ocular, and intranasal) for Dermatology, Ophthalmology, Cancer, Immunology (Glaucoma, neural degenerative disorders, HPV, LSIL/CIN I, cervical cancer, Scleroderma)
Non-invasive drug delivery technologies, biomolecular devices
Gene therapy, protein, and vaccine development
Nanomedicine, pharmaceutical development
Nanotoxicology (nanomaterials, bioimaging, biomarkers)
[Global Impact] [CBC] April 30, 2018 "Working with gene therapy to treat glaucoma"
[Waterloo Stories] July 5, 2012 "Revolutionary drug delivery"
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[Waterloo News] February 6, 2019 "Researchers find new treatment for Chlamydia"
[Waterloo News] April 16, 2018 "Developing new way to fight transmission of HIV"
Research Interests:
Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
Medicinal chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
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University Research Chair
Office of Research - Technology Transfer & Commercialization:
Research Interests:
[Waterloo Stories] August 28, 2018 "New sensor could help doctors monitor patient progress from a distance"
[Waterloo Stories] March 2, 2014 "Charge your phone while you shovel - and shiver"
Research Interests:
Biophysics of lipids and lipid-protein interactions
The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
Drug development and delivery systems, antimicrobial peptides in lung disorders
Fluorescence and atomic force microscopy
Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Research Interests:
Biomedical diagnosis
Targeted drug delivery
Environmental monitoring
DNA-based biosensors and functional polymers
Nanomaterials, (gold nanoparticles, liposomes, magnetic nanoparticles, quantum dots, graphene hydrogels, hybrid nanomaterials)
Bioinorganic / Bioanalytical chemistry
University Research Chair
[Waterloo Stories] February 27, 2013 "Waterloo researcher uses nano-materials to clean water"
Research Interests:
microrobots
We develop microrobots for medical applications. The goal is to develop more targeted, active, but less invasive strategies for drug or cell delivery with the help of wireless, autonomously moving microrobots. One strategy is to combine biological elements with artificial components in a biohybrid approach. The biological component (cells, molecules) can serve as power source, loading unit or structural unit.
One example is the "spermbot" - a sperm cell remotely controlled with magnetic fields: https://phys.org/news/2014-01-sperm-bots-desired-video.html
Another example is IRONSperm: a magnetically functionalized nonmotile sperm driven by magnetic fields:https://www.science.org/doi/10.1126/sciadv.aba5855
Inspired by the motion of sperm, we also develop small scale flexible magnetic robots for noninvasive surgery (coming soon). I am also interested in reproductive biology and research that elucidates reasons for infertility. We look into the mechanisms of sperm migration and some interesting phenomena, such as sperm bundling (publication online soon)
[Google Scholar]
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Research Interests:
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[Science Mag] June 6, 2016 "This desert moss can water itself with fog"
[Nature] June 08, 2016 "How desert moss drinks from air"
[PNAS] June 22, 2017 "Cavitation onset caused by acceleration"
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[Linkedin]
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Alternate Location:
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Awards:
[CBB Events] November 15, 2019 "Professor Shaker organizes a Health Canada Regulatory insights Workshop"
[CNN] November 11, 2019 "Scientists develop sensor to save children and pets from hot car deaths"
[Waterloo News] October 29, 2019 "Advancing healthcare through innovative technology"
[Inside Digital Health] June 3, 2019 "Study: Radar Monitors Sleep with Accuracy Comparable to Current Standards"
[Waterloo News] June 28, 2018 "AI and radar technologies could help diabetics manage their disease"
[Engineering News] June 28, 2018 "Researchers developing a prick-free glucose monitor"
[RD Magazine] June 28, 2018 "AI and Radar Technologies Could Help Diabetics Manage Their Disease"
[Engineering News] July 5, 2016 "Waterloo wins big with tiny power device"
Research Interests:
Drug discovery, delivery systems and nanomedicine
Gene therapy, microbial genetics
Oncology, Antiviral therapeutics design
Anti-bacterials
Acne cosmeceutical design
Phage-based biotechnology
Viral exclusion systems
Cosmeceuticals
Vaccine design (dementia), bacteriophage-based biotechnology, use of coliphages to design and construct vectors for the development of novel vaccines, pharmaceuticals and gene delivery systems, and the identification and application of novel phage genomic anti-bacterial genes with potential phage therapy applications.
Strategic management in Pharmacy; healthcare reform
Research Interests:
Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
Structure, function and pharmacology of calcium channels and sodium channels
Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Research Interests:
Enhanced drug delivery systems, gene therapy
Associative polymers for environmentally friendly coatings
Sustainable nanomaterials (cellulose nanocrystals)
Atom Transfer Radical Polymerization (ATRP) and stimuli responsive polymeric systems
Polymer-surfactant interactions
Magnetic nanoparticles for novel separation processes
University Research Chair
Research Interests:
Nanomaterials, nanodevices, biosensors for applications in food processing, bioreactors and biotechnology, natural gas purification, fuel cell, and water purification
Nano-Bio Hybrids for Tissue Engineering and Medicine for drug delivery, tissue engineering and regenerative medicine
Bio-molecule assisted nanomaterial self-assembly
Health and environmental effects of engineered nanomaterials
Research Interests:
Medicinal chemistry/enzymology (treatment of prostate and breast cancer, diabetes)
Nanomedicine; development of novel antibiotics
Bionanomaterials; synthetic polymers and methodologies
Peptide, charbohydrate, nucleoside and nucleotide chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Science News] February 4, 2015 "Chemists develop new method to improve the discovery of antibiotics"
Research Interests:
Gene therapy and drug delivery systems (prostate and ovarian cancer treatment)
Polymeric nanomaterials, biopolymers
Novel surface active compounds (gemini surfactants)
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[CBB researcher story] July 21, 2015 "Vectors for gene therapy and improving drug solubility"
Research Interests:
Stem cells, nanofabrication and advancement of biomaterials in healthcare technologies to repair, replace or regenerate damaged tissue and organ structures
Fabrication and application of nano-structure for biomedical applications in neural, vascular, and cornea tissue engineering
Biomaterial approach to study ex-vivo pluripotent stem cell expansion
Modulation of cell behavior with nanotopography
Topography-regulation of stem cells lineage commitment and differentiation
Differentiation of adult and pluripotent stem cells with nanotopography
Research Interests:
Ultrasound imaging innovations: Complex flow imaging, High-performance beamforming platforms, Flow phantom design
Therapeutic ultrasound discoveries: Sonoporation, Micro/nanobubble cavitation, Wave-matter interactions, Cellular dynamics studies
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Office of Indigenous Relations.