Our People - Disease Modelling

Research Interests:

• Dynamics and control of MEMS
• Design of MEMS devices
• Micro-power generation
• Multi-body dynamics and control
• Biomechanics

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Research Interests:

• Identifying mechanisms linking physical exposures with knee osteoarthritis
• Global aim of preventing exposure-related musculoskeletal disorders

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Research Interests:

• Assistive Robotics and Rehabilitation Engineering

• Neuromechanical Modeling; Robot-Based System ID
• Human-Robot Interaction and Neural Control
• Movement Analysis and Sensorimotor Deficit Modeling
• Smart Implants and Prosthetics
• Intelligent Systems and Machine Learning 

Google Scholar

Research Interests:

• Treatment of neurological disorders (Alzheimer’s, Parkinson’s, and mental health conditions including schizophrenia and depression)

• Molecular pharmacology and pharmaceutical delivery

• Intracellular signaling pathways in neurons, and the role of cytoskeletal dynamics in the trafficking of receptors in neurons

ResearchGate

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Research interests:

• Infectious disease epidemiology
• Chronic disease epidemiology
• Spatial epidemiology
• Global health
• Big data analytics

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ResearchGate

[Hep Mag] February 23, 2017 "Opioid Addiction Treatment and Psychotherapy Tied to Less HIV Risk in Those With Hep C"

[Smart Sex Resource] July 17, 2017 "Substance use, social disparities and the evolution of HIV/HCV infections in British Columbia"

[Smart Sex Resource] November 5, 2018 "Effect of opioid-substitution therapy and mental health counseling on HIV risk among hepatitis C-infected individuals"

Research Interests:

• Health informatics

• Translational research in healthcare and medicine

• Health system integration
• Semantic interoperability
• Healthcare decision making and decision support
• Health data analytics
• Medical imaging informatics
• Patient safety
• Mobile health
• Wearable devices

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[Waterloo Stories] July 10, 2017 "Waterloo software improves care for kidney patients"

[CBB researcher story] July 21, 2015 "Data management in Health Care"

Research Interests:

• Effect of food, beverages, herbal products and other drugs on drug metabolism and disposition
• Investigation of the interaction between grapefruit juice and prescription medication
• pharmacokinetics

• drug metabolism

• pharmacogenomics

• drug interactions

• bioavailability/bioequivalence

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Research Interests:

• Mobile health technologies and social media in medication management

• Clinical and post-marketing phases of medication use

• Improve medication use and primary care via emerging technologies (mobile apps, social media)

• Pharmacy remuneration models and chronic disease management services in the community pharmacy setting

• Usability of mobile health applications and wearable activity trackers for older adults living with chronic disease.

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ResearchGate

​[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

​[Waterloo Stories] November 16, 2016 "The opioid crisis: How pharmacists can help save lives"

Research interests:

• Imaging, treatment, and prevention of diseases
• Fabrication and characterization of innovative biomaterials for drug delivery systems (nanoparticles, medical devices, biodegradable films, hydrogels, etc.)
• Vaccine development for protection against HIV and other diseases

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[Waterloo News] February 6, 2019 "Researchers find new treatment for Chlamydia"

[Waterloo News] April 16, 2018 "Developing new way to fight transmission of HIV"

Research interests:

• Cellular-scale retinal imaging and light safety for the eye.
• Pioneer of two-photon excited fluorescence imaging through the pupil of a living primate eye, which enabled my group to be the first to image translucent primate retinal ganglion cells in vivo.
• First to deploy in vivo fluorescence lifetime imaging ophthalmoscopy of the retina at the cellular scale in living human and non-human primate eyes.

Research Interests:

• Mathematical modelling in systems biology
• Control theory
• Synthetic biology

ResearchGate

​[Google Scholar]

[CBB researcher story] August 6, 2015 "Decreasing antibiotic resistance in bacteria"

[YouTube Lecture] September 30, 2014 "Model-based design in synthetic biology"

Research interests:

• Upper-extremity biomechanics 
• Orthopaedic biomechanics 
• Osteoarthritis
• Computational modeling 
• Imaging

[Google scholar profile]

Research Interests:

• Integrative cancer biology
• Combination of cancer treatments
• Nano-scale drug delivery
• Cancer stem cells
• Biomechanics

ResearchGate

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[Waterloo News] June 23, 2016 "Nanotechnology and math deliver two-in-one punch for cancer therapy resistance"

[Waterloo Stories] February 11, 2015 "Study finds new lethal combination of cancer drugs shrinks tumors"

[Waterloo Stories] January 16, 2018 "Math can predict how cancer cells evolve"

Research Interests:

• Integrative kidney physiology

• Biofluid dynamics

• Diabetes

• Hypertension

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March 29, 2018 "Canada 150 Research Chair joins Department of Applied Mathematics"

Research Interests:

• Biophysics of lipids and lipid-protein interactions

• The role of structural changes and physical properties of lipid template in controlling biological processes and diseases

• Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)

• Drug development and delivery systems, antimicrobial peptides in lung disorders

• Fluorescence and atomic force microscopy

• Kelvin probe force microscopy and single molecule force spectroscopy

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ResearchGate

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[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure

[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"

Research interests:

• Developing machine learning and statistical methods for genomics and proteomics data analysis using interpretable machine learning, reproducible (error-controlled) machine learning, and heterogeneous data integration
• Developing interpretation methods to find scientifically interesting and statistically confident hypotheses from complex biological data from single-cell genomics, mass spectrometry-based proteomics, and metagenomics

Research Interests:

• mHealth and wearable technology design
• Ubiquitous sensors for smart homes and remote patient monitoring
• Big data and health data analytics
• Technology to support longer independent living

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Research Gate

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[MaRS] April 26, 2018 "UbiLab team wins Healthy Behaviour Data Challenge"

Research Interests:

• RNA Biology
• Cell Biology
• Molecular Genetics
• Developmental Biology

Research Interests:

• Application of intelligent systems (hydrology, water resources, decision making in health, control of satellite communications, fault detection analysis)

• Optimization
• Mathematical programming, decision making under uncertainty
• Data mining

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Research Interests:

• Experimental biological physics
• Stochastic processes in physics and biology
• Pysiological constraints on bioproduct synthesis

Lab Equipment: Imagestream MkII with 488nm, 642nm and 785nm lasers; 60x magnification

[YouTube Lectures] Winter School on Quantitative Systems Biology 2015

Research Interests:

Research Interests:

• Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.

• Structure, function and pharmacology of calcium channels and sodium channels

• Structure and function and analysis of NALCN cation channel  and anti-calcium channel toxins

• The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.

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ResearchGate

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[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"

Research Interests:

• Biochemistry and molecular biology of programmed cell death

• Functional genomics of senescence (biological aging) and apoptosis

• Comparative aspects of senescence and stress including the role of hormones and the involvement of free radicals

• Applicable therapies for cancers, inflammatory diseases (arthritis and sepsis), and in the agricultural sector (enhance yield, develop tolerance to environmental stress and plant diseases, and increase the shelf-life of perishable produce)

The Royal Society of Canada Fellow

Research Interests:

Research Interests:

• Biomedical image processing and analysis (prostate, breast, lung and dermatological cancer analysis, retinal photoreceptor and blood vessel analysis, musculoskeletal kinematic analysis

• Remote sensing data processing and analysis (sea ice, underwater object, oil spill analysis)

• Perceptual based video and image processing (noise reduction, compression, enhancement)

• Computer vision and pattern recognition

• Multimedia management systems

• 3D graphics and game development

• Cognitive radio networks

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Google Scholar

Canada Research Chair in Medical Imaging Systems [Canada Research Chair Profile]

[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

[Waterloo News] [CBC News] [Gadgets] May 16, 2018, Co-authors discuss the use of aerobic fitness data from wearable tech to predict illness

[Waterloo News] May 15, 2018 "Researchers combine wearable technology and AI to predict the onset of health problems"

[Global Impact] [570 news] [Youtube] April 11, 2018 "How AI is helping doctors diagnose Cancer" 

[The Star] February 9, 2018 "How TheRedPin aims to take a swipe at the real estate industry"

[Waterloo News] June 7, 2017 "Artificial intelligence-driven imaging research makes diagnosing disease easier"

[Waterloo Stories] January 28, 2017 "Artificial intelligence and the Waterloo-Toronto tech supercluster"

[Waterloo Stories] May 20, 2016 "Breakthrough tech helps doctors more accurately diagnose cancer"

[CBB researcher story] January 9, 2013 "Improving Early Diagnosis to Save Lives"

[Waterloo Stories] January 9, 2013 "Making it harder for cancer to hide"

[YouTube Lecture] October 1, 2014 "Integrative systems for biomedical imaging and analysis"

Research interests:

• Vision rehabilitation
• Systems for optimizing patient care outcomes
• Retinal disease
• Pharmacology.

Research Interests:

• Stem cells, nanofabrication and advancement of biomaterials in healthcare technologies to repair, replace or regenerate damaged tissue and organ structures

• Fabrication and application of nano-structure for biomedical applications in neural, vascular, and cornea tissue engineering

• ​Biomaterial approach to study ex-vivo pluripotent stem cell expansion

• Modulation of cell behavior with nanotopography

• Topography-regulation of stem cells lineage commitment and differentiation

• Differentiation of adult and pluripotent stem cells with nanotopography

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