Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Research Interests:
Research Interests:
drug metabolism
pharmacogenomics
drug interactions
bioavailability/bioequivalence
Research Interests:
Intelligent drug delivery system design (dermal, transdermal, transmucosal, ocular, and intranasal) for Dermatology, Ophthalmology, Cancer, Immunology (Glaucoma, neural degenerative disorders, HPV, LSIL/CIN I, cervical cancer, Scleroderma)
Non-invasive drug delivery technologies, biomolecular devices
Gene therapy, protein, and vaccine development
Nanomedicine, pharmaceutical development
Nanotoxicology (nanomaterials, bioimaging, biomarkers)
[Global Impact] [CBC] April 30, 2018 "Working with gene therapy to treat glaucoma"
[Waterloo Stories] July 5, 2012 "Revolutionary drug delivery"
Research interests:
[Science Direct] August 10, 2018 "Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study"
[Nature] August 27, 2019 "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors"
Research interests:
Research Interests:
Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
Medicinal chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
Research interests:
Research Interests:
University Research Chair
Office of Research - Technology Transfer & Commercialization:
Research Interests:
[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"
[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"
[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"
[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"
[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"
Research Interests:
Biophysics of lipids and lipid-protein interactions
The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
Drug development and delivery systems, antimicrobial peptides in lung disorders
Fluorescence and atomic force microscopy
Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Research interests:
Research interests:
Research Interests:
[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"
[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"
Research Interests:
Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
Structure, function and pharmacology of calcium channels and sodium channels
Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Research Interests:
Medicinal chemistry/enzymology (treatment of prostate and breast cancer, diabetes)
Nanomedicine; development of novel antibiotics
Bionanomaterials; synthetic polymers and methodologies
Peptide, charbohydrate, nucleoside and nucleotide chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Science News] February 4, 2015 "Chemists develop new method to improve the discovery of antibiotics"
Research Interests:
Gene therapy and drug delivery systems (prostate and ovarian cancer treatment)
Polymeric nanomaterials, biopolymers
Novel surface active compounds (gemini surfactants)
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[CBB researcher story] July 21, 2015 "Vectors for gene therapy and improving drug solubility"
Research Interests:
Biopharmaceuticals (therapeutics, treatment of autoimmune diseases, prevent rejection of organ transplants)
Industrial biomanufacturing and biotechnology (fermentation, food ingredients, enzymes, biofuels)
Environmental management (bioremediation of carcinogenic environmental pollutants, filtration, chromatography)
The Royal Society of Canada Fellow
[YouTube Lecture] September 29, 2014 "Biofuels and Waste Treatment"
[YouTube Lecture] September 19, 2013 "Industrial Biotechnology: Current developments and trends"
[UW Eng-e-news] August 14, 2013 "Engineering Life-enhancing research"
[Waterloo Stories] May 3, 2013 "Can bacteria help create a cheaper fuel for our cars?"
[CBB researcher story] December 6, 2012 "Bringing Bioengineering and Biotechnology to its Fullest Potential"
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Office of Indigenous Relations.