Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Research Interests:
Research Interests:
Assistive Robotics and Rehabilitation Engineering
Research Interests:
Viral vector drug delivery
Biological nano-particles (Virus-Like Particles or VLPs)
Vaccines, gene therapy, gene expression, genetic diseases
Baculovirus Bioprocessing
Process dynamics of virus-based systems for the production of complex biologics such as viral vectors and vaccines
Development of strategies using multiple viruses to obtain recombinant products in cell culture
[YouTube Lecture] September 30, 2014 "Tools and strategies for complex biologics production in animal cells: applications to insect and mammalian cell culture"
[YouTube] January 26, 2011 "Research Profile: Marc Aucoin"
Research Interests:
Biomedical optics
Tissue optics and spectroscopy
Ultrafast optics, coherence tomography, sensing, imaging
Confocal and fluorescence microscopy
Skin cancer detection
Atomic, Molecular and Optical Physics
Research Interests:
Research Interests:
Chemical process control - Robust control, Nonlinear control, Model Predictive Control (MPC)
Systems biology - modeling, control and optimization of biological processes, metabolic flux analysis, dynamic metabolic flux models, run-to-run (batch to batch) optimization of pharmaceutical process
Monitoring/Fault Detection of chemical and biological/biotechnological processes - Multivariate statistical methods for monitoring and fault detection, Inferential (soft) sensors
Research Interests:
Confocal microscopy and ophthalmoscopy, measurement of refractive error
Retinal image quality
Optical effects of refractive surgery, reflections from the retina
Optical properties of the eye, monochromatic aberrations of the eye
Refractive properties of the crystalline lens and their changes with growth and accommodation
Eye-imaging systems for treatment and diagnosis
Biophysics, bio-photonics, and Vision Science.
[Research2Reality] May 8, 2015 "Early Alzheimer's Diagnosis: Imaging the Living Eye"
[YouTube Lecture] October 1, 2014 "Optics of the Eye as a Window on the Brain"
[YouTube] February 12, 2013 "Melanie Campbell AAAS Profile"
[Waterloo Stories] February 12, 2013 "An early test for Alzhemer's disease"
[Waterloo Stories] January 22, 2013 "Early test for Alzheimer's may rely on the eyes"
Office of Research - Technology Transfer & Commercialization:
Research Interests:
Orthopaedic biomechanics (ACL, knee mechanics)
Biomedical device design
Tissue engineering
Implant design
Research Interests:
Bacterial molecular genetics
Functional genomics, metagenomics, genome engineering
Metabolic functions
Synthetic biology, bioplastics and bioproducts
[Biology News] December 21, 2016 "Waterloo biologist part of a research collaboration creating new genetic toolbox"
[Royal Canadian Institute Lecture] November 8, 2015 "Genome Engineering. Should we do it? (Can we afford not to?)"
[YouTube Lecture] September 30, 2014 "Mining microbial metagenomes"
[YouTube Lecture] September 19, 2013 "Mining metagenomes for bioplastics and other useful bioproducts"
[CBB researcher story] November 29, 2012 "Breaking Ground in Open Resource Metagenomics"
Research Interests:
Nano-Biomedical engineering, biochemistry, molecular cell biology
Colloid and Surface Science (surface chemistry, absorption kinetics, thermodynamics)
Polymer materials, CO2
Energy storage and conversion, battery systems and alternative energy
Drug and gene delivery, genomics
Lipid bilayer and cell membrane actions
University Research Chair
Research Interests:
Biochemical engineering
Microbial biotechnology
Synthetic and molecular biology
Genetic, metabolic and protein engineering
Biopharmaceuticals (to treat autoimmune diseases and prevent rejection of organ transplants)
Biomanufacturing, bioprocessing technologies (biological strain construction, bioreaction cultivation, biofuels, bioproduct recovery and purification)
[Waterloo Stories] May 3, 2013 "Can bacteria help create a cheaper fuel for our cars?"
[UW Eng-e-news] August 14, 2013 "Engineering Life-enhancing research"
Research Interests:
Canada Research Chair in Fish and Environmental Immunology [Canada Research Chair Profile]
[UW Science News] June 15, 2018, Waterloo Biologist mentors local teen, the 2018 International BioGENEius Challenge winner
[Waterloo Stories] January 22, 2018 "Vaccines not protecting farmed fish from disease"
[Waterloo Stories] February 13, 2014 "True love makes pacific salmon healthier"
[YouTube] October 9, 2013 "Science Scoop - For the love of fish!"
[Waterloo Stories] September 9, 2013 "Video conferencing connects Waterloo biologist to young students"
Research Interests:
Research Interests:
Intelligent drug delivery system design (dermal, transdermal, transmucosal, ocular, and intranasal) for Dermatology, Ophthalmology, Cancer, Immunology (Glaucoma, neural degenerative disorders, HPV, LSIL/CIN I, cervical cancer, Scleroderma)
Non-invasive drug delivery technologies, biomolecular devices
Gene therapy, protein, and vaccine development
Nanomedicine, pharmaceutical development
Nanotoxicology (nanomaterials, bioimaging, biomarkers)
[Global Impact] [CBC] April 30, 2018 "Working with gene therapy to treat glaucoma"
[Waterloo Stories] July 5, 2012 "Revolutionary drug delivery"
Research interests:
[Waterloo News] February 6, 2019 "Researchers find new treatment for Chlamydia"
[Waterloo News] April 16, 2018 "Developing new way to fight transmission of HIV"
Research Interests:
Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
Medicinal chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
Research Interests:
NSERC Industrial Research Chair in Water Treatment [NSERC Profile]
[Waterloo Stories] March 14, 2013 "Protecting our drinking water for 20 years"
Research interests:
Research Interests:
[CBB researcher story] August 6, 2015 "Decreasing antibiotic resistance in bacteria"
[YouTube Lecture] September 30, 2014 "Model-based design in synthetic biology"
Research Interests:
University Research Chair
Office of Research - Technology Transfer & Commercialization:
Research Interests:
Production of bio-energy (electricity, H2, and CH4) and bio-chemicals from biomass
Thermodynamic/kinetic analyses on microbial metabolisms in engineered and natural systems
Microbial ecology in engineered biological systems
Environmental biotechnology
Nutrients recovery from organic waste and wastewater
[Waterloo Stories] March 18, 2014 "Giving people a simple way to test their drinking water"
[Waterloo Stories] May 10, 2013 "Can bacteria create green energy?"
Research Interests:
Biophysics of lipids and lipid-protein interactions
The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
Drug development and delivery systems, antimicrobial peptides in lung disorders
Fluorescence and atomic force microscopy
Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Research Interests:
Integrated microsystems for clinical and environmental monitoring
Combining complementary metal-oxide-semiconductor (CMOS) integrated circuits with novel materials, structures, or devices to enable non-traditional life science and bio-diagnostic applications
CMOS-integrated biochemical assays
Semiconductor integrated circuits and sensors, design and test of 3D integrated circuits
Micro/nano fabrication, lab-on-a-chip devices
Electrochemical biosensors
Electrophysiology
DNA sequencing
Image sensors
Research Interests:
Bioinformatics tools (protein structures, genome mapping, conducting homology searches)
Protein structure prediction, and automated NMR protein structure determination
Stem cell image recognition
Canada Research Chair in Bioinformatics [Canada Research Chair Profile]
The Royal Society of Canada Fellow
[Waterloo Stories] April 5, 2013 "RSVP: Responding to a need"
[Waterloo Stories] July 6, 2012 "Solving life's big issues, one question at a time"
Research Interests:
Biochemistry and enzymology
Thermostable Biocatalyst and dehydrogenases (Biofuel/Bioethanol production, pharmaceutical and other industrial processes)
Enzyme evolution and protein engineering, microbial physiology, molecular biology
Sulfur reduction and energy metabolism, alcohol metabolism
Electron transfer and flavoproteins.
Office of Research - Technology Transfer & Commercialization:
Research Interests:
microrobots
We develop microrobots for medical applications. The goal is to develop more targeted, active, but less invasive strategies for drug or cell delivery with the help of wireless, autonomously moving microrobots. One strategy is to combine biological elements with artificial components in a biohybrid approach. The biological component (cells, molecules) can serve as power source, loading unit or structural unit.
One example is the "spermbot" - a sperm cell remotely controlled with magnetic fields: https://phys.org/news/2014-01-sperm-bots-desired-video.html
Another example is IRONSperm: a magnetically functionalized nonmotile sperm driven by magnetic fields:https://www.science.org/doi/10.1126/sciadv.aba5855
Inspired by the motion of sperm, we also develop small scale flexible magnetic robots for noninvasive surgery (coming soon). I am also interested in reproductive biology and research that elucidates reasons for infertility. We look into the mechanisms of sperm migration and some interesting phenomena, such as sperm bundling (publication online soon)
[Google Scholar]
Research interests:
Research Interests:
Protein structure, functions, evolution (yeast, mammalian cell lines, plant-bacterial)
Bioinformatics, systematics and protein evolution
Research Interests:
Proteins: energetics, kinetics, mechanisms, structure, dynamics, folding, function, evolution, engineering and design, thermodynamics, kinetics (ALS, Alzheimer's, Parkinson's, prions, cancer)
High resolution nuclear magnetic resonance spectroscopy (fluorescence, CD, NMR, FTIR, DLS)
Optical spectroscopies
Bioinformatics and computational modelling
Biocomputing and protein engineering
[Waterloo News] November 24, 2015 "New insights into protein structure could change the future of biomedicine"
[Chemistry News] August 20, 2014 "Chemist Elizabeth Meiering takes on the ALS ice bucket challenge"
Research interests:
Research interests:
Research Interests:
Machine learning and reasoning under uncertainty (artificial intelligence, computational statistics, decision and control theory)
Health informatics (assistive technologies, behaviour recognition, smart walkers, Alzheimer’s monitoring)
Natural language understanding (dialogue management, semantic analysis)
[National Post] May 11, 2018, weighs in on how Google's A.I. personal assistant sparks concerns about future of communication
[The Record] May 8,2018, have ties with a new Montreal sports analytics research lab in Kitchener
[Markets Insider] February 5, 2018 "Borealis AI increases brain power by adding top AI talent"
[The Globe and Mail] February 4, 2018 "How we can leverage AI to bridge academia and business"
[Waterloo Stories] April 12, 2013 "Breaking the fall: Smart walker will help prevent injuries"
Research Interests:
Sea water desalination, hydrogen production for fuel cells, CO2 recovery from fossil fuel power plants
Membrane processes, catalysis, organic or inorganic nanoparticles
Porous materials, materials and sol-gel integrative chemistry
Nanostructures and superlattices
Sustainable processes
Microemulsions
[YouTube Lecture] September 29, 2014 "Biofuels and Waste Management"
Research Interests:
Protein and DNA separation analysis towards disease diagnosis and drug discovery
Biosensing and Devices (bacterial, proteins, fluorescence)
Living cell analysis and water toxicity testing
Lab-on-a-Chip technology (point-of-care biomedical diagnosis , chemical detection, protein separation and identification, environmental testing)
Micro-scale fluid mechanics, droplet microfluidics and nanofluidics
Canada Research Chair in Lab-on-a-Chip Technology [Canada Research Chair Profile]
[Waterloo Stories] June 14, 2012 "Creating the tiny future of science"
Research Interests
[Linkedin]
Alternate Location:
Research Interests:
Awards:
[CBB Events] November 15, 2019 "Professor Shaker organizes a Health Canada Regulatory insights Workshop"
[CNN] November 11, 2019 "Scientists develop sensor to save children and pets from hot car deaths"
[Waterloo News] October 29, 2019 "Advancing healthcare through innovative technology"
[Inside Digital Health] June 3, 2019 "Study: Radar Monitors Sleep with Accuracy Comparable to Current Standards"
[Waterloo News] June 28, 2018 "AI and radar technologies could help diabetics manage their disease"
[Engineering News] June 28, 2018 "Researchers developing a prick-free glucose monitor"
[RD Magazine] June 28, 2018 "AI and Radar Technologies Could Help Diabetics Manage Their Disease"
[Engineering News] July 5, 2016 "Waterloo wins big with tiny power device"
Research Interests:
[Engineering News] March 9, 2018 "Finds manure can yield energy and ease global warming"
Research Interests:
Drug discovery, delivery systems and nanomedicine
Gene therapy, microbial genetics
Oncology, Antiviral therapeutics design
Anti-bacterials
Acne cosmeceutical design
Phage-based biotechnology
Viral exclusion systems
Cosmeceuticals
Vaccine design (dementia), bacteriophage-based biotechnology, use of coliphages to design and construct vectors for the development of novel vaccines, pharmaceuticals and gene delivery systems, and the identification and application of novel phage genomic anti-bacterial genes with potential phage therapy applications.
Strategic management in Pharmacy; healthcare reform
Research Interests:
Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
Structure, function and pharmacology of calcium channels and sodium channels
Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Research Interests:
Electrophysiological characterization of neuromuscular disorders
Autonomous and knowledge systems
Machine perception and sensors
Image processing and analysis, pattern analysis and recognition
EMG signal decomposition, simulation and quantitative EMG and DQEMG
Biomedical engineering
Research interests:
Research interests:
Research Interests:
Stem cells, nanofabrication and advancement of biomaterials in healthcare technologies to repair, replace or regenerate damaged tissue and organ structures
Fabrication and application of nano-structure for biomedical applications in neural, vascular, and cornea tissue engineering
Biomaterial approach to study ex-vivo pluripotent stem cell expansion
Modulation of cell behavior with nanotopography
Topography-regulation of stem cells lineage commitment and differentiation
Differentiation of adult and pluripotent stem cells with nanotopography
Research Interests:
Biopharmaceuticals (therapeutics, treatment of autoimmune diseases, prevent rejection of organ transplants)
Industrial biomanufacturing and biotechnology (fermentation, food ingredients, enzymes, biofuels)
Environmental management (bioremediation of carcinogenic environmental pollutants, filtration, chromatography)
The Royal Society of Canada Fellow
[YouTube Lecture] September 29, 2014 "Biofuels and Waste Treatment"
[YouTube Lecture] September 19, 2013 "Industrial Biotechnology: Current developments and trends"
[UW Eng-e-news] August 14, 2013 "Engineering Life-enhancing research"
[Waterloo Stories] May 3, 2013 "Can bacteria help create a cheaper fuel for our cars?"
[CBB researcher story] December 6, 2012 "Bringing Bioengineering and Biotechnology to its Fullest Potential"
Research Interests:
Bionanomaterials and “soft” interfaces
Biomimetic adhesion, bio-integrated devices
Nanoparticles synthesis, functionalization and dispersion, nanocomposites
Polymers, interfacial phenomena and surface chemistry
Advanced coating and adhesive bonding technology
[Waterloo Stories] December 16, 2016 "New Gecko Gripper can be used in manufacturing and medicine"
[YouTube Video] June 11, 2015 "Zebra Mussel-inspired Electrically Conductive Polymer Nanofiber"
[Waterloo Stories] September 16, 2013 "Waterloo researcher is developing nano-glue for electronics"
Office of Research - Technology Transfer & Commercialization:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.