Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Biomedical optics
Tissue optics and spectroscopy
Ultrafast optics, coherence tomography, sensing, imaging
Confocal and fluorescence microscopy
Skin cancer detection
Atomic, Molecular and Optical Physics
Research Interests:
My research program combines a fundamental in-vitro research approach, examining the time varying response of the lumbar spine tissues, with in-vivo human research, examining biological responses to cumulative loading exposure from both pain generating and tissue altering/injuring perspectives. Work in my laboratories involves developing approaches to assess workplace cumulative loading exposure and injury in conjunction with in-vitro tissue mechanics studies investigating the injury pathways from repetitive loading. Currently, quantifying the influence of modifiers such as repetition and magnitude of exposure to establish the relationship between cumulative loading and low back pain is a major focus in my research. This knowledge will complement existing epidemiological data, linking cumulative loading and low back pain, for setting exposure limits and helping to prevent low back injuries.
Research Interests:
Confocal microscopy and ophthalmoscopy, measurement of refractive error
Retinal image quality
Optical effects of refractive surgery, reflections from the retina
Optical properties of the eye, monochromatic aberrations of the eye
Refractive properties of the crystalline lens and their changes with growth and accommodation
Eye-imaging systems for treatment and diagnosis
Biophysics, bio-photonics, and Vision Science.
[Research2Reality] May 8, 2015 "Early Alzheimer's Diagnosis: Imaging the Living Eye"
[YouTube Lecture] October 1, 2014 "Optics of the Eye as a Window on the Brain"
[YouTube] February 12, 2013 "Melanie Campbell AAAS Profile"
[Waterloo Stories] February 12, 2013 "An early test for Alzhemer's disease"
[Waterloo Stories] January 22, 2013 "Early test for Alzheimer's may rely on the eyes"
Office of Research - Technology Transfer & Commercialization:
Research Interests:
Biomedical and scientific imaging
Computer vision and video analysis
Image processing, segmentation/classification
Multiresolution techniques
Automated interpretation of SAR (synthetic aperture radar)
Remote sensing
Stochastic models
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[The Record] May 8,2018, have ties with a new Montreal sports analytics research lab in Kitchener
Research interests:
[Science Direct] August 10, 2018 "Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study"
[Nature] August 27, 2019 "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors"
Research Interests:
Theoretical molecular biophysics and soft matter (chromosomes, polymers, electrostatics)
Polymer physics for chromosome organization in a cell
Confined polymers (chain topology, spatial organization, and dynamics)
Electrostatic modification of lipid membranes
Physical basis for cell selectivity of antimicrobial peptides
Polyelectrolytes and polyampholytes
Research interests:
Research Interests:
Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
Medicinal chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
Research interests:
Research Interests:
University Research Chair
Office of Research - Technology Transfer & Commercialization:
Research Interests:
[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"
[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"
[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"
[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"
[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"
Research Interests:
[CBB researcher story] July 29, 2015 "Image processing to automate early glaucoma diagnosis"
Research Interests:
Biophysics of lipids and lipid-protein interactions
The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
Drug development and delivery systems, antimicrobial peptides in lung disorders
Fluorescence and atomic force microscopy
Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Research Interests:
Research Interests:
Biomedical diagnosis
Targeted drug delivery
Environmental monitoring
DNA-based biosensors and functional polymers
Nanomaterials, (gold nanoparticles, liposomes, magnetic nanoparticles, quantum dots, graphene hydrogels, hybrid nanomaterials)
Bioinorganic / Bioanalytical chemistry
University Research Chair
[Waterloo Stories] February 27, 2013 "Waterloo researcher uses nano-materials to clean water"
Research Interests:
microrobots
We develop microrobots for medical applications. The goal is to develop more targeted, active, but less invasive strategies for drug or cell delivery with the help of wireless, autonomously moving microrobots. One strategy is to combine biological elements with artificial components in a biohybrid approach. The biological component (cells, molecules) can serve as power source, loading unit or structural unit.
One example is the "spermbot" - a sperm cell remotely controlled with magnetic fields: https://phys.org/news/2014-01-sperm-bots-desired-video.html
Another example is IRONSperm: a magnetically functionalized nonmotile sperm driven by magnetic fields:https://www.science.org/doi/10.1126/sciadv.aba5855
Inspired by the motion of sperm, we also develop small scale flexible magnetic robots for noninvasive surgery (coming soon). I am also interested in reproductive biology and research that elucidates reasons for infertility. We look into the mechanisms of sperm migration and some interesting phenomena, such as sperm bundling (publication online soon)
[Google Scholar]
Research Interests:
[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"
[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"
Research Interests:
Protein and DNA separation analysis towards disease diagnosis and drug discovery
Biosensing and Devices (bacterial, proteins, fluorescence)
Living cell analysis and water toxicity testing
Lab-on-a-Chip technology (point-of-care biomedical diagnosis , chemical detection, protein separation and identification, environmental testing)
Micro-scale fluid mechanics, droplet microfluidics and nanofluidics
Canada Research Chair in Lab-on-a-Chip Technology [Canada Research Chair Profile]
[Waterloo Stories] June 14, 2012 "Creating the tiny future of science"
Research Interests
[Linkedin]
Research Interests:
Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
Structure, function and pharmacology of calcium channels and sodium channels
Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Research Interests:
Electrophysiological characterization of neuromuscular disorders
Autonomous and knowledge systems
Machine perception and sensors
Image processing and analysis, pattern analysis and recognition
EMG signal decomposition, simulation and quantitative EMG and DQEMG
Biomedical engineering
Research Interests:
Ultrasound imaging innovations: Complex flow imaging, High-performance beamforming platforms, Flow phantom design
Therapeutic ultrasound discoveries: Sonoporation, Micro/nanobubble cavitation, Wave-matter interactions, Cellular dynamics studies
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.