Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Research Interests:
Treatment of neurological disorders (Alzheimer’s, Parkinson’s, and mental health conditions including schizophrenia and depression)
Molecular pharmacology and pharmaceutical delivery
Intracellular signaling pathways in neurons, and the role of cytoskeletal dynamics in the trafficking of receptors in neurons
Research Interests:
Research Interests:
drug metabolism
pharmacogenomics
drug interactions
bioavailability/bioequivalence
Research Interests:
Mobile health technologies and social media in medication management
Clinical and post-marketing phases of medication use
Improve medication use and primary care via emerging technologies (mobile apps, social media)
Pharmacy remuneration models and chronic disease management services in the community pharmacy setting
Usability of mobile health applications and wearable activity trackers for older adults living with chronic disease.
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Waterloo Stories] November 16, 2016 "The opioid crisis: How pharmacists can help save lives"
Research interests:
[Waterloo News] February 6, 2019 "Researchers find new treatment for Chlamydia"
[Waterloo News] April 16, 2018 "Developing new way to fight transmission of HIV"
Research Interests:
Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
Medicinal chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
Research interests:
Research Interests:
University Research Chair
Office of Research - Technology Transfer & Commercialization:
Research Interests:
[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"
[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"
[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"
[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"
[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"
Research Interests:
Biophysics of lipids and lipid-protein interactions
The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
Drug development and delivery systems, antimicrobial peptides in lung disorders
Fluorescence and atomic force microscopy
Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Research interests:
Research interests:
Research Interests:
[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"
[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"
Research interests:
Research Interests:
Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
Structure, function and pharmacology of calcium channels and sodium channels
Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Research Interests:
Medicinal chemistry/enzymology (treatment of prostate and breast cancer, diabetes)
Nanomedicine; development of novel antibiotics
Bionanomaterials; synthetic polymers and methodologies
Peptide, charbohydrate, nucleoside and nucleotide chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Science News] February 4, 2015 "Chemists develop new method to improve the discovery of antibiotics"
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.