Mike Beazely

Research Interests:
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Treatment of neurological disorders (Alzheimer’s, Parkinson’s, and mental health conditions including schizophrenia and depression)
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Molecular pharmacology and pharmaceutical delivery
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Intracellular signaling pathways in neurons, and the role of cytoskeletal dynamics in the trafficking of receptors in neurons
Javad Behravan

Research Interests
- Breast cancer, glioblastoma and acute lymphoblastic leukemia (ALL)
- Vaccine development
- Immunotherapy
- Phage based nanomedicine
Andrea Edginton

Research Interests:
- Pharmacokinetics of drugs and environmental contaminants
- Optimization of drug therapy
- Physiologically-based Pharmacokinetic (PBPK) modeling and simulation (prediction of the absorption, distribution and elimination of a compound within an organism)
David Edwards

Research Interests:
- Effect of food, beverages, herbal products and other drugs on drug metabolism and disposition
- Investigation of the interaction between grapefruit juice and prescription medication
- pharmacokinetics
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drug metabolism
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pharmacogenomics
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drug interactions
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bioavailability/bioequivalence
Kelly Grindrod

Research Interests:
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Mobile health technologies and social media in medication management
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Clinical and post-marketing phases of medication use
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Improve medication use and primary care via emerging technologies (mobile apps, social media)
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Pharmacy remuneration models and chronic disease management services in the community pharmacy setting
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Usability of mobile health applications and wearable activity trackers for older adults living with chronic disease.
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Waterloo Stories] November 16, 2016 "The opioid crisis: How pharmacists can help save lives"
Emmanuel Ho

Research interests:
- Imaging, treatment, and prevention of diseases
- Fabrication and characterization of innovative biomaterials for drug delivery systems (nanoparticles, medical devices, biodegradable films, hydrogels, etc.)
- Vaccine development for protection against HIV and other diseases
[Waterloo News] February 6, 2019 "Researchers find new treatment for Chlamydia"
[Waterloo News] April 16, 2018 "Developing new way to fight transmission of HIV"
John Honek

Research Interests:
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Methionine chemistry and biochemestry (amino acid methionine and its roles in proteins, cellular pathways and its functions)
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Bionanomaterials, bionanotechnology (for novel drug carriers, molecular foundations for nanodevices)
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Medicinal chemistry
- Enzymology
- Bioorganic chemistry
- Protein structure and function
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
Lyndon Jones

Research Interests:
- Clinical trial design
- Contact lens performance
- Drug delivery
- Ocular biomaterials
- Proteins at interfaces
University Research Chair
Office of Research - Technology Transfer & Commercialization:
Subha Kalyaanamoorthy

Research Interests:
- Design/discovery of potential therapeutics to target various diseases
- Understanding the structure and pharmacology of membrane proteins
- Development of in silico methods/tools for sequence, structure and functional analysis
- Inferring the structure-function evolution of proteins
- Protein engineering for biotechnology and pharmaceutical applications
[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"
[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"
[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"
[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"
[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"
Zoya Leonenko

Research Interests:
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Biophysics of lipids and lipid-protein interactions
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The role of structural changes and physical properties of lipid template in controlling biological processes and diseases
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Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)
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Drug development and delivery systems, antimicrobial peptides in lung disorders
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Fluorescence and atomic force microscopy
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Kelvin probe force microscopy and single molecule force spectroscopy
[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure
[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"
Kaylena Ehgoetz Martens

John Mielke

Research interests:
- Neurobiological embedding of adversity
- Biological characteristics that influence outcome from brain injury
- Drug development, biomarkers
- Stroke; biological characteristics that influence outcomes from brain injury
Praveen Rao Perampalli Nekkar

Research Interests:
- Drug discovery
- Rational drug design and medicinal chemistry
- Cancer therapy
- Treatment of neurological disorders (Alzheimer's, Parkinson's)
- Drug discovery/rational design
- Synthesis and biological evaluation of novel organic molecules and peptides/peptidomimics as therapeutic agents
[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"
[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"
Tejal Patel

David Spafford

Research Interests:
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Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.
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Structure, function and pharmacology of calcium channels and sodium channels
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Structure and function and analysis of NALCN cation channel and anti-calcium channel toxins
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The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.
[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"
Scott Taylor

Research Interests:
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Medicinal chemistry/enzymology (treatment of prostate and breast cancer, diabetes)
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Nanomedicine; development of novel antibiotics
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Bionanomaterials; synthetic polymers and methodologies
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Peptide, charbohydrate, nucleoside and nucleotide chemistry
[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners
[Science News] February 4, 2015 "Chemists develop new method to improve the discovery of antibiotics"