Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
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Wednesday, April 26, 2023 — 12:10 PM to 1:00 PM EDT
Abstract
DNA aptamers are single-stranded DNA oligonucleotides that can selectively bind to target molecules. They can be used for the detection of various metabolites and proteins as disease biomarkers. Our lab recently discovered new aptamers that can bind to caffeine, uric acid and lactate, and converted them to highly sensitive and selective fluorescent biosensors. In addition, we have isolated aptamers that can bind to exosomes, which could be used for the isolation and detection of exosomes as important disease biomarkers. Finally, we have isolated aptamers that can bind to pig cornea and established an aptamer-enhanced ocular drug delivery method to treat dry eye diseases.