Bioinformatics Seminar - Prof. Yang Zhang Export this event to calendar

Friday, February 14, 2014 — 10:30 AM EST

Presenter: Yang Zhang, Ph.D.
Associate Professor, Biological Chemistry, University of Michigan, Ann Arbor
Associate Professor, Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor

Title: Protein design and protein structure prediction

Location: DC 2585

A number of computational methods developed by the Zhang lab have been demonstrated in the CASP experiments to be the world's best for protein structure prediction and function annotation. The lab is currently working on extending the developed protein modelling algorithms for protein design and structure-based drug discovery. They are especially interested in modeling G protein-coupled receptors and the interactions with the associated ligands with the purpose of developing new drugs to regulate these interactions.

You can also visit Yang Zhang's webpage for more information.

Abstract: Protein structure prediction aims to determine spatial location of every atom in protein molecules from the amino acid sequence by computational simulations, while protein design is a reverse procedure of protein folding and structure prediction aiming to identify new sequences of desirable structure and function. In this talk, I first review recent progress in computer-based protein structure prediction, and show that a new approach combining template-based and ab initio modeling can break though the barrier of physics-based protein folding and result in correct folding of proteins larger than 150 residues. Next, we apply a similar evolutionary based approach to design new functional XIAP (X-linked Inhibitor of Apoptosis Protein) BIR3 domains that bind Smac peptide but not inhibit caspase-9 activity, representing an exciting potential to change the caspase-9 initiated apoptosis pathway through computational protein design.

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