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DTSTART:20250309T070000
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DTSTART;TZID=America/Toronto:20250610T093000
SEQUENCE:0
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URL:https://uwaterloo.ca/centre-for-theoretical-neuroscience/events/william
 -lytton-suny-downstate-applied-math-seminar
LOCATION:MC - Mathematics & Computer Building 200 University Avenue West Ro
 om 5501 (look for Colloquium Rooms) Waterloo ON N2L 3G1 Canada
SUMMARY:William Lytton SUNY Downstate (Applied Math Seminar)
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. William Lytton\, SUNY Downstate Health Sciences\
 nUniversity\n\nTitle: Neurons and synapses working together happily in bra
 in health\;\nnot so happily in brain disease\n\nAbstract: At first approxi
 mation\, we currently think of the brain as a\nset of neurons as nodes con
 nected by directed edges\, akin to the\nmathematical description of an Erd
 ős–Rényi graph model. It is now\ntime to redirect attention on the ind
 ividual neurons\, the massive\ncomplex entities that are often a locus of 
 disease progression and may\nalso be an additional locus of computation. 
  I will focus on the\nrole of the cortical corticospinal cell in Parkinso
 n's disease (PD)\nand in migraine/ischemia. In both cases a class of neur
 on becomes\ndamaged as an effect of disease: the effect becomes a site for
  the\nburgeoning disorder.\n\nMore generally\, I wish to refocus on cell p
 hysiology as a basis of\nbrain function. This will help us to better expla
 in how cell pathology\nproduces dysfunction in neurodegenerative disorders
  such as\nAlzheimer's\, Parkinson's\, and mild cognitive impairment. The r
 oles\nplayed by particular neuron types in performing the computations tha
 t\nunderlie brain function will provide a new Neuron-based Computational\n
 Theory (NCT) to complement and augment the current dominant\nSynapse-based
  Computational Theory (SCT)\, which gave us\nHebbian/Hopfieldian cell asse
 mblies reified in modern\nlarge-language models (LLMs).
DTSTAMP:20260404T180347Z
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