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DTSTART:20250309T070000
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UID:69f2ed2185939
DTSTART;TZID=America/Toronto:20251201T133000
SEQUENCE:0
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DTEND;TZID=America/Toronto:20251201T143000
URL:https://uwaterloo.ca/chemical-engineering/events/paste-biomaterials-tra
 umatic-brain-injury-and-cartilage
LOCATION:PSE - Pearl Sullivan Engineering Room 7303 200 University Ave West
  Waterloo ON N2L 3G1 Canada
SUMMARY:Paste-like Biomaterials for Traumatic Brain Injury and Cartilage\nR
 epair
CLASS:PUBLIC
DESCRIPTION:Bioinks for bioprinting and injectable biomaterials share a com
 mon\nthread in fluid mechanics (rheology) in that the flow properties of\
 nthe material are crucial to successful application. Beyond\nshear-thinnin
 g behavior\, properties including yield stress and\nstorage modulus recov
 ery are important\, and speak to the\n‘paste-like’ quality of the mat
 erial. Two applications in\nregenerative medicine will be highlighted: tra
 umatic brain injury and\ncartilage injury.\n\nIn severe traumatic brain in
 juries\, often a portion of the skull is\nsurgically removed to relieve pr
 essure from the brain swelling\, but a\n2nd surgery is required to fill t
 hat gap in the skull. We have\nproposed a paste-like biomaterial that cou
 ld potentially eliminate\nthe 2nd surgery. \n\nOur goal is to implant the 
 biomaterial at the time of the original\nsurgery\,to be crosslinked to sta
 y in place\, flexible to allow the\nbrain to swell\, deliver anti-inflamma
 tory drugs locally to the brain\,\nand then transition into bone over tim
 e. Initial studies with bone\nregeneration and drug delivery have shown p
 romise.
DTSTAMP:20260430T054817Z
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