Designing Smart Nanocarriers: Consolidating Multiple Functions into a Single Macromolecular Platform
Dr. Ashok Kakkar
Department of Chemistry
Monday, December 2, 2013
C2-361 (Reading Room)
Abstract: Considering the complexity of nanomedicine, challenges in therapeutics and theranostics have provoked the design of tailor made nanocarriers that can perform desired tasks with high efficiency, and which can combine multiple functions into a single scaffold of a nanostructure. Dendrimers and miktoarm stars have offered tremendous opportunities in this regard. We have recently developed facile synthetic routes to such branched and hyperbranched architectures in which i) pharmaceutical agents can be physically encapsulated or covalently conjugated for efficient delivery; and ii) orthogonally functionalized building blocks can be utilized to assemble a multivalent platform with therapeutic, imaging and targeting capabilities.
In this presentation, we shall elaborate on this macromolecule based nanotechnology, and discuss its potential in drug delivery. We shall demonstrate for example how such nanocarriers can deliver drugs efficiently at physiologically relevant temperatures, and how one can easily construct multivalent nanoconjugates which can perform multiple tasks for an effective drug therapy.