Chemistry Seminar Series: Dr. Michael KerrExport this event to calendar

Wednesday, October 2, 2013 — 2:30 PM EDT

Functionalization of Indoles: Applications to the Total Synthesis of Natural Products

Dr. Michael Kerr
Department of Chemistry
Western University

Wednesday, October 2, 2013
2:30 p.m.
C2-361 (Reading Room)

Abstract:  We have developed methods for the efficient functionalization of the indole moiety at either the 3- or 2-posiiton using carbenoids or radicals derived from 1,3-dicarbonyl species.1  Recent progress in methods development will be discussed as well as the application of these methods to the synthesis of natural products both completed2 and in progress. 
Kerr Seminar
1. [1] a) Johansen, M.B.; Kerr, M.A. Direct Functionalization of Indoles: Copper-Catalyzed Malonyl Carbenoid Insertions. Org. Lett. 2010, 12, 4956. b) Magolan, J.; Kerr, M.A. Expanding the Scope of Mn(OAc)3-Mediated Cyclizations: Synthesis of the Tetracyclic Core of Tronocarpine. Org. Lett. 2006, 8, 4561. c) Gibe, R.; Kerr, M.A.  Convenient preparation of indolyl malonates via carbenoid insertion.  J. Org. Chem. 2002, 67, 6247-6249. 
2. Magolan, J; Carson, C.A.; Kerr, M.A.  Total synthesis of (+/-)-mersicarpine.  Org. Lett., 2008, 10 1437.
 

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