Chemistry Seminar Series: Professor Jeffrey AtkinsonExport this event to calendar

Thursday, December 6, 2012 — 2:30 PM EST

From antioxidants to radiomitigants: Or how I learned to stop worrying and love the bomb

Dr. Jeffrey Atkinson
Department of Chemistry and Biochemistry
Brock University

Thursday, December 6, 2012
MC 4041
2:30 p.m.

Abstract:  The initial steps of apoptosis involve the selective peroxidation of cardiolipin lipid species inside the mitochondrion. This oxidative chemistry is catalyzed by a partially unfolded form of cytochrome c that occurs when cardiolipin membrane asymmetry is lost and cytochrome c complexes with this lipid are formed. Following earlier work with inhibitors of the oxidative metabolism of vitamin E, we have developed a family of heterocycle substituted fatty acids that inhibit cytochrome c peroxidase activity and can protect cells and mice from lethal doses of radiation.

S M T W T F S
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
  1. 2019 (107)
    1. November (1)
    2. October (3)
    3. September (18)
    4. August (4)
    5. July (9)
    6. June (9)
    7. May (15)
    8. April (13)
    9. March (15)
    10. February (14)
    11. January (6)
  2. 2018 (115)
    1. December (5)
    2. November (14)
    3. October (11)
    4. September (5)
    5. August (5)
    6. July (4)
    7. June (5)
    8. May (8)
    9. April (13)
    10. March (12)
    11. February (15)
    12. January (18)
  3. 2017 (108)
  4. 2016 (125)
  5. 2015 (115)
  6. 2014 (98)
  7. 2013 (104)
  8. 2012 (85)
  9. 2011 (10)