Chemistry Seminar Series: Professor Rebecca JockuschExport this event to calendar

Wednesday, November 2, 2011 — 2:30 PM to 3:30 PM EDT

Intrinsic properties of biomolecules revealed by fluorescence and FRET measurements of trapped, mass-selected ions

Professor Rebecca Jockusch
Department of Chemistry
University of Toronto

Abstract: The function of biological molecules is dependent on properties including biomolecular structure, stability, dynamics and interactions. While the complexity of the native environment is desirable for function, isolation of biological molecules from their normal environment provides valuable simplification, allowing study of their intrinsic properties. My research program combines trapping mass spectrometry with optical spectroscopic techniques in order to characterize properties of biomolecules and their complexes in a highly-controlled gas-phase environment. Our laboratory has developed a flexible interface for performing spectroscopic experiments on gaseous molecular ions and clusters stored in a quadrupole ion trap mass spectrometer. In particular, we are pursing the use of fluorescence and Fluorescence Resonance Energy Transfer (FRET) techniques to probe ion conformation. In this talk, I will discuss results from fluorescence and photodissociation action spectroscopy of several small organic dye molecules, a model chromophore of the Green Fluorescent Protein (GFP) and the first spectra and lifetime measurements showing the occurrence of FRET in gaseous peptides.

Location 
C2 - Chemistry 2
Room 361
200 University Ave West

Waterloo, ON N2L 3G1
Canada

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