The complexities of nanoparticle tumor targeting
Professor Warren Chan
Department of Chemistry
University of Toronto
Friday, October 19, 2012
C2-361 (Reading Room)
Abstract: Nanoparticles of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics. Strategies that can reproducibly prepare colloidal nanoparticles of a wide range of geometries with a tight size distribution have been achieved and unique size and shape dependent optical, magnetic, electrical, and biological properties have been discovered. A broad of range of applications of nanoparticles have been demonstrated. In spite of what has been achieved so far, a complete understanding of how cells and animals interact with nanoparticles of well-defined sizes remains poorly understood. This has led to the inability to rationally design nanoparticles for cancer applications or has led to the inability to establish a definitive conclusion on the toxicity of nanomaterials. This presentation will focus the effect of nanoparticle parameters on cellular interaction and tumor targeting. We will also describe how the outcomes of these fundamental studies have led to the engineering of artificial nanoparticle-targets to improve tumor targeting. The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity.
Biography: Dr. Chan is currently a Full Professor in the Institute of Biomaterials and Biomedical Engineering at the University of Toronto. He also holds the Canadian Research Chair in Bionanotechnology and is affiliated with the Department of Materials Science and Engineering, the Terrence Donnelly Center for Cellular and Biomolecular Research Chemistry, Chemistry and Chemical Engineering. His research interest is in the development of nano- and microtechnology for cancer and infectious disease diagnosis. He has received the BF Goodrich Young Inventors Award, Lord Rank Prize Fund award in Optoelectronics (England), and Dennis Gabor Award (Hungary). Dr. Chan received his B.S. degree from the University of Illinois in 1996 and Ph.D. degree from Indiana University in 2001. He did his post-doctoral training at the University of California (San Diego). He will be starting as an Associate Editor of ACS Nano and is currently on the Editorial Advisory Board of the journals Nanomedicine, Advanced Healthcare Materials, and Journal of the Automatic Laboratory Automation.