Chemistry Seminar Series: Robert Batey

Robert Batey ​​​​​​
Department of Chemistry
University of Toronto

Thursday, January 16, 2019
2:30 p.m.
C2-361 (Reading Room)

Abstract: 

Biologically active natural products including alkaloids, terpenoids, macrocyclic peptides and depsipeptides serve as an inspiration for many synthetic chemists. Their often complex and diverse structures can pose many interesting synthetic challenges. They can also act as potential lead structures for the development of pharmaceuticals or biological probe molecules, including anticancer, antibiotic, antiviral, antifungal, anti-inflammatory and CNS activities. Recent progress toward macrocyclization strategies for depsipeptide and peptide formation, as well as alkaloids will be described. Example targets include the ADEPs (e.g., A54556A), the syringolins, nagelamide J, and the agrobactins.