Natural Product Inspired Synthetic Methods Development: Targetting Macrocycles and Alkaloids
Department of Chemistry
University of Toronto
Thursday,
January
16,
2019
2:30
p.m.
C2-361
(Reading
Room)
Abstract:
Biologically active natural products including alkaloids, terpenoids, macrocyclic peptides and depsipeptides serve as an inspiration for many synthetic chemists. Their often complex and diverse structures can pose many interesting synthetic challenges. They can also act as potential lead structures for the development of pharmaceuticals or biological probe molecules, including anticancer, antibiotic, antiviral, antifungal, anti-inflammatory and CNS activities. Recent progress toward macrocyclization strategies for depsipeptide and peptide formation, as well as alkaloids will be described. Example targets include the ADEPs (e.g., A54556A), the syringolins, nagelamide J, and the agrobactins.
