Chemistry Seminar Series: Sophie RousseauxExport this event to calendar

Thursday, January 23, 2020 — 2:30 PM EST

Strategies for Selective C–C and C–O Bond Cleavage in Cyclopropanols and Nitriles

Sophie Rousseaux ​​​
Canada Research Chair in Organic Chemistry
Department of Chemistry
University of Toronto

Thursday, January 23, 2019
2:30 p.m.
C2-361 (Reading Room)

Abstract

Research in the Rousseaux group focuses on the development of new synthetic methods involving reactive organometallic intermediates and/or Ni catalysis. In this presentation, I will describe our efforts to develop new synthetic methods in two areas.

In the first part of this talk, I will discuss our recent work on the functionalization of cyclopropanol derivatives through selective C–C and C–O bond cleavage. Reactions involving electrophilic metal homoenolates1 will be presented as well as Ni-catalyzed cross-couplings of cyclopropanols.2

In part two, I will describe our current efforts in developing new synthetic methods for the preparation of nitrile-containing building blocks that use inexpensive and less toxic nitrile-transfer reagents.3 Our recent work on the development of Ni-catalyzed reductive transnitrilation reactions will also be presented.4

1. (a) Mills, L. R.; Barrera Arbelaez, L. M.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2017, 139, 11357–11360; (b) West, M. S.; Mills, L. R.; McDonald, T. R.; Lee, J. B.; Ensan, D.; Rousseaux, S. A. L. Org. Lett. 2019, 21, 8409–8413.

2. (a) Mills, L. R.; Zhou, C.; Fung, E. Org. Lett. 2019, 21, 8805–8809; (b) Mills, L. R.; Monteith, J. J.; Rousseaux, S. A. L. Unpublished.

3. Alazet, S.; West, M. S.; Patel, P.; Rousseaux, S. A. L. Angew. Chem. Int. Ed. 2019, 58, 10300-10304; Mills, L. R.; Rousseaux, S. A. L. Tetrahedron 2019, 75, 4298-4306.

4. Mills, L. R.; Graham, J.; Patel, P.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2019, 141, 19257–19262.

Location 
C2 - Chemistry 2
Room 361
200 University Avenue West

Waterloo, ON N2L 3G1
Canada

S M T W T F S
26
27
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
  1. 2021 (36)
    1. December (1)
    2. November (2)
    3. October (5)
    4. August (1)
    5. July (2)
    6. June (2)
    7. May (1)
    8. April (5)
    9. March (10)
    10. February (8)
  2. 2020 (48)
    1. November (1)
    2. October (1)
    3. September (2)
    4. August (1)
    5. July (6)
    6. June (2)
    7. April (1)
    8. March (9)
    9. February (11)
    10. January (15)
  3. 2019 (131)
  4. 2018 (115)
  5. 2017 (108)
  6. 2016 (125)
  7. 2015 (115)
  8. 2014 (98)
  9. 2013 (104)
  10. 2012 (85)
  11. 2011 (10)