Interactions of amphiphilic molecules with lipid membranes
Professor Heiko Heerklotz
Leslie Dan Faculty of Pharmacy
University of Toronto
Tuesday, April 16, 2013
C2-361 (Reading Room)
Abstract: We are pursuing a detailed physico-chemical understanding of the interactions of detergents, biosurfactants, and other amphiphiles with lipid membranes. This allows us to find explanations for phenomena in biology and to develop applications in biotechnology and pharmaceutics.
The seminar will address the fundamental behaviour of lipid-detergent systems, detergent-resistant membranes, and the selective and synergistic permeabilization of membranes by bacterial lipopeptides that are used as "green" pesticides for crop protection. Key techniques are time-resolved fluorescence spectroscopy and isothermal titration calorimetry.