Michael Palmer carries out research in biochemistry. His research focuses on the interaction of peptides and proteins with biological membranes. One current area of interest is the action mode of lipopeptide antibiotic daptomycin, as well as the mechanism of bacterial resistance to it.
- Pore-forming toxins
Michael Palmer's research focuses on protein-lipid interaction in biological membranes:
- Structure and function of bacterial pore-forming toxins
- Structure and function of lipopeptide antibiotics
- Development of fluorescence methods to study protein-protein and protein-membrane interaction
His experiments involve a range of methods including fluorescence, protein chemistry, and molecular biology.
Michael Palmer teaches both undergraduate and graduate courses. Recent course offerings include metabolism, biochemical pharmacology, biological membranes, and computer methods in protein structure and function.
Recent publications include
- Moreira, R.; Barnawi, G.; Beriashvili, D.; Palmer, M. and Taylor, S. D. (2018). The effect of replacing the ester bond with an amide bond and of overall stereochemistry on the activity of daptomycin, Bioorg. Med. Chem. 27 : 240-246.
- Barnawi, G.; Noden, M.; Taylor, R.; Lohani, C.; Beriashvili, D.; Palmer, M. and Taylor, S. D. (2018). An Entirely Fmoc Solid Phase Approach to the Synthesis of Daptomycin Analogs, Biopolymers, Peptide Science, 111(1), e23094.
- Beriashvili, D.; Taylor, R.; Kralt, B.; Abu Mazen, N.; Tayler, S. and Palmer, M. (2018). Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation, Chem. Phys. Lipids .
- Jin, T.; Brefo-Mensah, E.; Fan, W.; Zeng, W.; Li, Y.; Zhang, Y. and Palmer, M. (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity., J. Biol. Chem. 293 : 11867-11877.
- Mehdizadeh Gohari, I.; Brefo-Mensah, E. K.; Palmer, M.; Boerlin, P. and Prescott, J. F. (2018). Sialic acid facilitates binding and cytotoxic activity of the pore-forming Clostridium perfringens NetF toxin to host cells, PLoS One 11:e0206815Lohani CR, Taylor R, Palmer M, Taylor SD. Solid-phase synthesis and in vitro biological activity of a Thr4→Ser4 analog of daptomycin (2015) Bioorg Med Chem Lett. 25:5490-5494
Please see Michael Palmer's Google Scholar profile for a current list of his peer-reviewed articles.
Awards and Distinctions
- Boehringer Ingelheim Award, 1999
- 'DGHM - Förderpreis' (young investigator award, German Society of Hygiene and Microbiology), 1998
University of Waterloo Affiliations
- Cross appointed to the Department of Biology
- Member of the Institute of Biochemistry & Molecular Biology
- Waterloo Centre for Microbial Research (member)
Professional Associations and Service
- Chemistry Department seminar coordinator, 2011-present
- Chemistry Department Awards Committee, 2008-present
- Science Building Committee, 2008-15
The following news stories have featured Michael Palmer's research:
2000 Habilitation Medical Microbiology, University of Mainz, Germany
1991 Dr. med. (M.D.), University of Mainz, Germany
1987 Approbation als Arzt (Approved Physician), University of Giessen, Germany