Michael Palmer

• Fluorescence
• Antibiotics
• Membranes
• Lipopeptides
• Pore-forming toxins

Michael Palmer's research focuses on protein-lipid interaction in biological membranes:

• Structure and function of bacterial pore-forming toxins
• Structure and function of lipopeptide antibiotics
• Development of fluorescence methods to study protein-protein and protein-membrane interaction

His experiments involve a range of methods including fluorescence, protein chemistry, and molecular biology.

Michael Palmer teaches both undergraduate and graduate courses. Recent course offerings include metabolism, biochemical pharmacology, biological membranes, and computer methods in protein structure and function.

Recent publications include

• Lohani CR, Taylor R, Palmer M, Taylor SD. Solid-phase synthesis and in vitro biological activity of a Thr4→Ser4 analog of daptomycin (2015) Bioorg Med Chem Lett. 25:5490-5494
• Lohani CR, Taylor R, Palmer M, Taylor SD. Solid-phase total synthesis of daptomycin and analogs (2015) Org Lett. 17:748-51
• Zhang T, Muraih J, Tishbi N, Herskowitz J, Victor RL, Silverman J,  Uwumarenogie S, Taylor S, Mintzer E, Palmer M. Cardiolipin prevents membrane translocation and permeabilization by daptomycin (2014) J Biol Chem 289:11584-11591
• Zhang T, Muraih J, MacCormick B, Palmer M. Daptomycin forms cation- and size-selective pores in model membranes (2014) Biochim Biophys Acta 1838:2425-2430
• Pokrajac L, Harris JR, Sarraf N, Palmer M. Oligomerization and hemolytic properties of the C-terminal domain of pyolysin, a cholesterol-dependent cytolysin (2013) Biochem Cell Biol. 91:59-66

Please see Michael Palmer's Google Scholar profile for a current list of his peer-reviewed articles.

• Boehringer Ingelheim Award, 1999  
• 'DGHM - Förderpreis' (young investigator award, German Society of Hygiene and Microbiology), 1998

• Cross appointed to the Department of Biology
• Member of the Institute of Biochemistry & Molecular Biology
• Waterloo Centre for Microbial Research (member)

• Chemistry Department seminar coordinator, 2011-present
• Chemistry Department Awards Committee, 2008-present     
• Science Building Committee, 2008-15

The following news stories have featured Michael Palmer's research:

• February 4, 2016:  Chemists develop new method to improve the discovery of antibiotics

• April 17, 2015:  Waterloo scientists win Seed Fund for antibiotic and lung disease research

2000 Habilitation Medical Microbiology, University of Mainz, Germany

1991 Dr. med. (M.D.), University of Mainz, Germany

1987 Approbation als Arzt (Approved Physician), University of Giessen, Germany