PHARM 600s


PHARM 602 Grant Writing in the Sciences (0.50) LECCourse ID: 013817
The course is designed to teach the student how to critically review the literature, ask the right scientific questions, generate hypotheses, and write a professional curriculum vita and a fundable grant proposal. The course will include lectures from the instructor and guest speakers, small group discussion, student presentations and a final written grant proposal.

PHARM 603 Selected Topics in Medicinal Chemistry (0.50) LECCourse ID: 013818
This course provides an introduction to basic principles in medical chemistry such as physiochemical properties, drug design and pharmacological actions. A brief overview of the theory and application of computer aided drug design principles will provide a basic understanding of the "in silico" drug design concepts. The student will develop an understanding toward the concepts of peptide/petidomimetic design as therapeutic agents. A series of case studies on clinical drugs will be presented with major emphasis on their design, synthesis, reaction mechanisms and structure-activity relationship studies. A section of the course will address the pathophysiology and pharmacology of diseases affecting the central nervous system. In addition, learning activities and assignments include a term paper submission and in class presentation of current topics in medicinal chemistry.

PHARM 604 Gene Therapy (0.50) LECCourse ID: 013819
Gene therapy offers extraordinary potential to treat both inherited and acquired diseases by using the body's own machinery to produce a therapeutic compound or protein, or up-regulate/down-regulate specific cellular processes. This course will examine the various extra- and intracellular barriers to DNA transfection, and the common vectors used in gene therapy. Various routes of administration, such as injected, inhaled, and transdermal will be discussed in terms of their challengers, and the successes of recent formulations described in the literature.

PHARM 605 Physical Chemistry and Application of Surfactants (0.50) LECCourse ID: 013820
Surface active compounds, more commonly known as surfactants are found in nearly every aspect of day to day life, including motor oils, pharmaceuticals, cosmetics, detergents, and paints and inks to name a few. This course will introduce the student to the structures of classical and emerging classes of surfactants and their fundamental properties that make these systems so useful. The self-assembly of these compounds into micelles will be discussed in detail using both thermodynamic and kinetic modules and modern methods of characterizing these systems will be examined. The application of surfactants in a variety of industries will be introduced. The capstone activity of this course will entail a critical analysis of a relevant recent journal article, and presentation to the class.

PHARM 606 Neuroscience in the 21st Century (0.50) LECCourse ID: 013821
Intensively examines medical and technological advances in neuroscience. Students will first develop a deep understanding of the structure and function of the central nervous system, neuronal cell biology and physiology, and neurotransmission. Explores selected CNS disease states and identify mechanisms of neuropathology by biological, environmental, and iatrogenic causes. Advances in technology and nanotechnology is and will continue to transform the treatment of diseases of the nervous system and these issues will be explored by expert guest lecturers.

PHARM 607 Advanced Pharmaceutical Analysis (0.50) LECCourse ID: 013822
This course provides an introduction to modern spectroscopic methods with emphasis on pharmaceutical analysis. First few lectures will cover the theory and application of UV-Vis and IR spectroscopy. A review of NMR spectroscopy will focus on commonly used techniques such as 1H NMR and 13C NMR and their application. The student will get a practical experience in spectroscopic methods for structural elucidation by using UVS-VIS, IR and NMR spectrometers. In addition, a section will address the theory and application of mass spectrometry. Examples of drug molecules/pharmaceuticals and their spectroscopic characteristics will be discussed. In addition, learning activities and assignments include problem sets and structural elucidation of an unknown organic molecule.

PHARM 608A Selected Topics in Pharmaceutical Sciences 1 (0.50) LEC,RDG,TUTCourse ID: 013919
This course will discuss specialized topics that are related to the research interests of faculty members in the field of Pharmaceutical Sciences. Topics could include, for example, the areas of drug delivery systems, diabetes, bacteriophage derived therapeutics, central nervous disorders, medicinal chemistry, pharmacokinetics, biophysical methods, bionanotechnology, nanomedicine among others. This course may be presented in any of the following formats, reading based, lecture based, project based or online learning.
Instructor Consent Required

PHARM 609 Advanced Pharmacokinetics (0.50) LECCourse ID: 014082
This course details the concepts and techniques involved in the quantitative description of absorption, distribution, metabolism, and elimination of drugs. Basic concepts in pharmacokinetics will be thoroughly discussed along with special topics of non-linear kinetics, pharmacodyanmics, therapeutic drug monitoring, drug-drug interactions and the mechanistic basis for pharmacokinetic variability. Modeling and simulation exercises using software common to the industry will be completed by the student incorporating non-compartmental, compartmental and pysiologically-based pharmacokinetic modeling.

PHARM 610 Topics in Drug Development (0.50) LECCourse ID: 014083
This course will cover all aspects of drug development, from basic research through to post-marketing surveillance of drug safety and efficacy. Faculty members from the UW School of Pharmacy and beyond will provide their expertise on aspects of the drug development process. Students will gain valuable knowledge and appreciation of the drug development process from "bench to bedside". Using real-life drug research problems, students will learn how identification of disease stat pathophysiology directs drug design, how medicinal chemistry optimizes lead molecule creation, how drug dosage forms are designed, pharmacokinetic studies, how animal models are used to test the efficacy and toxicity of lead compounds, the design and evaluation of clinical trials, drug manufacturing, perspectives from the pharmaceutical industry, as well as business and regulatory issues.