Paolo Dominelli

Research interests 

My laboratory seeks to understand the integrative mechanisms underpinning the oxygen cascade under physiologically relevant conditions of exercise and hypoxia. This is accomplished by studying the conductance of oxygen across multiple physiological systems (pulmonary, cardiac and muscle) and their interaction. Using concepts of homeostasis, regulation, feedback, redundancy and acclimatization/adaptation, my laboratory builds upon reductionists findings to understand whole-body physiology.

Graduate supervision and student opportunities

• Research volunteer
• Undergraduate thesis 
• MSc thesis
• PhD thesis
• Postdoctoral fellowship (PDF)

Please email me to discuss available opportunities.

Graduate studies application details

Teaching, expertise, tools and technologies 

• Respiratory physiology
• Exercise physiology
• Work of breathing
• Ventilatory limitations to exercise
• Pulmonary gas exchange
• Cardiorespiratory interactions

Courses 

KIN 408 - Cardiovascular physiology and pathophysiology

KIN 470 - Pulmonary physiology during exercise

Education 

BHK, University of British Columbia

MSc, University of British Columbia

PhD, University of British Columbia

PDF, Mayo Clinic

Selected publications

See PubMed for publications.

Dominelli, P.B., Katayama, K., Vermuelen, T.D., Stuckless, T.J.R., Brown, C.V., Foster, G.E., Sheel, A.W. Work of breathing influences muscle sympathetic nerve activity during semi-recumbent cycle exercise. Acta Physiologica, 2019; 225: e13212.

Dominelli, P.B., Sanz, J.R., Cross, T.J., Baker, S.E., Wiggins, C., Welch, B.T., Joyner, M.J. Sex differences in large conducting airway anatomy. Journal of Applied Physiology, 2018; 125: 960-965.

Dominelli, P.B., Archiza, B., Ramsook, A.R., Mitchell, R.A., Peters, C.M., Molgat-Seom, Y., Henderson, W.R., Koehle, M.S., Boushel, R., Sheel, A.W. Effects of respiratory muscle work on respiratory and locomotor blood flow during exercise. Experimental Physiology, 2017; 102.11: 1535-1547.

Dominelli, P.B., Molgat-Seon, Y., Griesdale, D.E.G., Peters, C.M., Blouin, J.S., Sekhon, M., Dominelli, G.S., Henderson, W.R., Foster, G.E., Romer, L.M., Koehle, M.S., Sheel, A.W. Sex differences in quadriceps muscle fatigue: effects of arterial oxygen content and respiratory muscle work. Journal of Physiology, 2017; 595: 5227-5244

Dominelli, P.B., Henderson, W.R., Sheel, A.W. A proportional assist ventilator to experimentally unload the respiratory muscles during exercise in humans. Experimental Physiology.

Dominelli, P.B., Render, J.N., Molgat-Seon, Y., Foster, G.E., Romer, L.M., Sheel, A.W. Oxygen cost of exercise hyperpnoea is greater in women compared with men. Journal of Physiology, 2015; 593.8: 1965-1979

Dominelli, P.B., Foster, G.E., Dominelli, G.S., Henderson, W.R., Koehle, M.S., McKenzie, D.C., Sheel, A.W. Exercise-induced arterial hypoxaemia and the mechanics of breathing in healthy young women. Journal of Physiology, 2013; 591.12: 3017-3034