Drugs and Drug Delivery Systems Targeting Amyloid-β in Alzheimers Disease

TitleDrugs and Drug Delivery Systems Targeting Amyloid-β in Alzheimers Disease
Publication TypeJournal Article
Year of Publication2015
AuthorsRobinson, M., B. Y. Lee, and Z. Leonenko
JournalAIMS Molecular Science
Volume2
Start Page332
Issue3
Pagination332-358
Date Published07/2015
KeywordsAlzheimer's disease, amyloid, amyloid aggregation, blood brain barrier, drug delivery systems, inhibitor drugs, nanotechnology
Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no cure and limited treatment solutions that are unable to target any of the suspected causes. Increasing evidence suggests that one of the causes of neurodegeneration is the overproduction of amyloid beta (Aβ) and the inability of Aβ peptides to be cleared from the brain, resulting in self-aggregation to form toxic oligomers, fibrils and plaques. One of the potential treatment options is to target Aβ and prevent self-aggregation to allow for a natural clearing of the brain. In this paper, we review the drugs and drug delivery systems that target Aβ in relation to Alzheimer's disease. Many attempts have been made to use anti-Aβ targeting molecules capable of targeting Aβ (with much success in vitro and in vivo animal models), but the major obstacle to this technique is the challenge posed by the blood brain barrier (BBB). This highly selective barrier protects the brain from toxic molecules and pathogens and prevents the delivery of most drugs. Therefore novel Aβ aggregation inhibitor drugs will require well thought-out drug delivery systems to deliver sufficient concentrations to the brain.

URLhttp://www.aimspress.com/article/10.3934/molsci.2015.3.332
DOI10.3934/molsci.2015.3.332
Refereed DesignationRefereed
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