Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation

TitleEffect of Metals on Kinetic Pathways of Amyloid-β Aggregation
Publication TypeJournal Article
Year of Publication2014
AuthorsHane, F., and Z. Leonenko
JournalBiomolecules
Volume4
Start Page101
Issue1
Pagination101-116
Date Published01/2014
KeywordsAlzheimer’s disease, amyloid aggregation, amyloid-metal effects, multiple pathways kinetics
Abstract

Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimer’s disease through a variety of mechanisms including increased amyloid-β affinity and redox effects. Recent reports have demonstrated that the amyloid-β monomer does not necessarily travel through a definitive intermediary en-route to a stable amyloid fibril structure. Rather, amyloid-β misfolding may follow a variety of pathways resulting in a fibrillar end-product or a variety of oligomeric end-products with a diversity of structures and sizes. The presence of metal ions has been demonstrated to alter the kinetic pathway of the amyloid-β peptide which may lead to more toxic oligomeric end-products. In this work, we review the contemporary literature supporting the hypothesis that metal ions alter the reaction pathway of amyloid-β misfolding leading to more neurotoxic species.

URLhttp://www.mdpi.com/2218-273X/4/1/101
DOI10.3390/biom4010101
Refereed DesignationRefereed
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