Interaction Forces of a Supported DOPC Bilayer in the Presnece of the General Anaesthetic Halothane: An Atomic Force Microscopy Study

TitleInteraction Forces of a Supported DOPC Bilayer in the Presnece of the General Anaesthetic Halothane: An Atomic Force Microscopy Study
Publication TypeJournal Article
Year of Publication2006
AuthorsShamrakov, L., Z. Leonenko, E. Finot, and D. Cramb
JournalAustralian Journal of Chemistry
Volume59
Start Page386
Pagination386-389
Date Published07/2006
Abstract

In this study atomic force microscopy (AFM) was used to study the effect of halothane on a supported dioleoylphosphatidylcholine (DOPC) bilayer under conditions of high anaesthetic loading. In a previous study we demonstrated that bilayer restructuring occurs as a result of halothane incorporation. Force measurements using AFM indicate an initial decrease in adhesive forces and compressibility between the bilayer and AFM tip, followed by an increase in adhesion properties as a function of incubation time. This effect is attributed to the location and dynamic redistribution of halothane within the bilayer.

URLhttp://www.publish.csiro.au/paper/CH06141.htm
DOI10.3410/f.30467.486967
Refereed DesignationRefereed