The research in the Martin Lab focuses on elucidating molecular mechanisms that promote the clearance of disease causing proteins in neurodegeneration, particularly Huntington disease (HD) and amyotrophic lateral sclerosis (ALS). We focus on the cellular pathway know as autophagy, which delivers toxic proteins and damaged organelles to the lysosome for degradation and recycling. In particular, we are interested in how autophagy proteins are directed to membranes within the cell.  

Our approach is highly collaborative and multi-faceted involving the identification of human SNPs, population genetics, protein characterization, chemical biology and high-resolution microscopy. Various aspects of these studies are performed in yeast, cell culture and mouse models.


The goal of the Martin Lab is to provide a highly collaborative and safe environment in the pursuit of outstanding science. We commit to training students, postdocs, and technicians so they can succeed in any scientific careers of their choosing.

  1. Dec. 3, 2018Identification of a Novel Caspase Cleavage Site in Huntingtin that Regulates Mutant Huntingtin Clearance

    On November 30, 2018, Science in the City profiled a recent publication in the FASEB Journal from Dr. Dale Martin in the laboratory of Dr. Michael Hayden at the Centre for Molecular Medicine and Therapeutics at UBC.

    Read more in Science in the City

    Read the publication in The FASEB Journal here

  2. Mar. 13, 2018The connection between Huntington disease and diet
    Istock illustration of a brain with neurons.

    Biology congratulates its newest faculty member, Dale Martin, on his latest paper.

Read all news
  1. Oct. 5, 2019Huntington Society of Canada Community Education Forum

    Hearts Full of Hope

    For the first time since the disease was identified by Dr. George Huntington in 1872, there is hope for treatments that target the root cause of HD, providing the HD Community with "hearts full of hope." 

All upcoming events