OUR RESEARCH GOAL
The research in the Martin Lab focuses on elucidating molecular mechanisms that promote the clearance of disease causing proteins in neurodegeneration, particularly Huntington disease (HD) and amyotrophic lateral sclerosis (ALS). We focus on the cellular pathway know as autophagy, which delivers toxic proteins and damaged organelles to the lysosome for degradation and recycling. In particular, we are interested in how autophagy proteins are directed to membranes within the cell.
Our approach is highly collaborative and multi-faceted involving the identification of human SNPs, population genetics, protein characterization, chemical biology and high-resolution microscopy. Various aspects of these studies are performed in yeast, cell culture and mouse models.
The goal of the Martin Lab is to provide a highly collaborative and safe environment in the pursuit of outstanding science. We commit to training students, postdocs, and technicians so they can succeed in any scientific careers of their choosing.
- Oct. 11, 2021
- Aug. 11, 2021
- Apr. 9, 2021
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry