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OUR RESEARCH GOAL

The research in the Martin Lab focuses on elucidating molecular mechanisms that promote the clearance of disease causing proteins in neurodegeneration, particularly Huntington disease (HD) and amyotrophic lateral sclerosis (ALS). We focus on the cellular pathway know as autophagy, which delivers toxic proteins and damaged organelles to the lysosome for degradation and recycling. In particular, we are interested in how autophagy proteins are directed to membranes within the cell.  

Our approach is highly collaborative and multi-faceted involving the identification of human SNPs, population genetics, protein characterization, chemical biology and high-resolution microscopy. Various aspects of these studies are performed in yeast, cell culture and mouse models.

OUR MISSION 

The goal of the Martin Lab is to provide a highly collaborative and safe environment in the pursuit of outstanding science. We commit to training students, postdocs, and technicians so they can succeed in any scientific careers of their choosing.

  1. Oct. 11, 2021Congrats to Lucia Liao for winning the Provost Doctoral Entrance Award

    Congratulations to Lucia Liao for winning the Provost Doctoral Entrance Award!  It goes to doctoral students with "...an outstanding record of research accomplishments and/or references citing significant future potential in research."

  2. Aug. 11, 2021The NeurdyPhagy Lab is awarded a CFI-JELF to purchase a new laser scanning confocal microscope

    https://uwaterloo.ca/science/news/faculty-science-researchers-awarded-funding-innovative-and

  3. Apr. 9, 2021The NeurdyPhagy Lab's first publication

    Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

    https://www.jove.com/t/62107/optimized-incorporation-alkynyl-fatty-acid-analogs-for-detection?status=a64113k

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