The research in the Martin Lab focuses on identifying and characterising therapeutics that reduce levels of mutant huntingtin, the causative agent of the neurodegenerative disease Huntington disease (HD), by repairing the protein clearance pathway of autophagy and gene silencing. Our approach is highly collaborative and multi-faceted involving the identification of human SNPs, population genetics, protein characterization, chemical biology and high-resolution microscopy. Various aspects of these studies are performed in yeast, cell culture or mice.
- Huntington disease
- Fatty acylation
- Cell Signaling
- Protein Expression and Purification
- Lipid Metabolism