Publications

myr-HTT
Neurons
DHHC
myr-HTT
1 / 3
Neurons
2 / 3
DHHC
3 / 3

​Select Publications

  • Lemarié, F.L., Schmidt, M.E., aron, N, Sanders, S.S., Nguyen, Y.T.N., Ko, S., Xu, X., Pouladi, M.A., Martin, D.D.O., Hayden, M.R. (2021) Resue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity. Neurobiology of Disease (In Press) https://doi.org/10.1016/j.nbd.2021.105479

  • Liao, L.M.Q., Gray, R.A.V., Martin, D.D.O. (2021) Optimized delivery of alkyne fatty acids for the detection of fatty acylation using Click Chemistry. J. Vis. Exp. e62107(170). PMID: 33900285

  • Martin, D.D.O., Kanuparthi. P., Holland, S.M., Sanders, S.S., Jeoung, H., Einarson, M., Jacobson, M., Thomas, G.M. (2018) Identification of novel inhibitors of DLK palmitoylation by High Content Screening. Scientific Reports 9(3632). PMID: 30842471. BioRxiv
  • Martin, D.D.O., Schmidt, M.E., Nguyen, Y.T., Lazic, N., Hayden, M.R. (2018) Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance. FASEB J 33(3): 3190-3197. PMID: 30823259. BioRxiv
  • Martin, D.D.O., Kay, C., Collins, J., Nguyen, Y.T., Slama, R. and Hayden, M.R. (2018) A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease. Sci Rep 8(1):8096. PMID: 29802276. BioRxiv
  • Ehrnhoefer, D.E., Martin, D.D.O., Qiu, X., Ladha, S., Skotte, N., Nguyen, Y.T.N., Vaid, K., Engemann, S., Franciosi, S., Hayden, M.N. (2017) Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington Disease. Acta Neuropathologica Communications 6(1):16 PMID: 29510748. BioRxiv
  • Martin, D.D.O. and Hayden, M.R. (2017) Role of Repeats in Protein Clearance. 545, 33–34 doi:10.1038/nature22489 Nature PMID: 28445458
  • Sanders, S.S.*, Martin, D.D.O.*1, Butland, S., Lavallée-Adam, M., Calzolari, D., Kay, C., Yates, J.R., Hayden, M.R. (2015) Assembly of the mammalian palmitoylome indicates a pivotal role for palmitoylation in neurodegeneration and cancer. 11(8): e1004405. PLoS Comp Bio PMID: 26275289
    • *contributed equally
  • Martin, D.D.O. & Hayden, M.R. (2015) Post-translational myristoylation at the cross roads of cell death and autophagy and neurodegeneration. 43(2); 229-234. Biochem Soc Trans PMID: 25849922
  • Wong, B.K.Y.*, Ehrnhoefer, D.E.*, Graham, R.K., Martin, D.D.O., Uribe, V., Ladha, S., Stanek, L.M, Franciosi, S., Qiu, X., Deng, Y., Kovalik, V., Zhang, W., Pouladi, M.A., Shihabuddin, L., Hayden, M.R. (2015) Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. (*co-first authors) Neurobiology of Disease (76):24-36. PMID: 25583186
  • Martin, D.D.O., Ladha, S., Ehrnhoefer, D.E., Hayden, M.R. (2015) Autophagy in Huntington Disease and Huntingtin in Autophagy. Trends in Neuroscience 38(1):26-35 PMID: 25282404
  • Martin, D.D.O., Heit,R.J., Yap, M.C., Davidson, M.W., Hayden, M.R, Berthiaume, L.G. (2014) Identification of a posttranslationally myristoylated autophagy inducing domain released by caspase cleavage of Huntingtin. Hum Mol Genet 23(12):3166-3179 PMID: 24459296
  • Martin, D.D.O.,  Ahpin, C.Y., Heit, R.J., Perinpanayagam, M.A., Yap, M.C., Veldhoen, R.A., Goping, I.S., Berthiaume, L.G. (2012) Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKCɛ; a case study. FASEB J. 26(1):13-28 PMID: 21965604
  • Martin, D.D.O.*, Beauchamp, E.*, Berthiaume, L.G. (2011) Post-translational myristoylation: fat matters in cellular life and death (*denotes co-first authors). Biochimie 93(1):18-31. PMID: 21056615
  • Yap, Y.C.*, Kostiuk, M.A.*, Martin, D.D.O., Perinpanayagam, M.A., Hak, P.G., Siddam, A., Majjigapum, J.R., Rajaiah, G., Keller, B.O., Prescher, J.A., Wu, P., Bertozzi, C.R., Falck, J.R., Berthiaume, L.G. (2010) Rapid and selective detection of fatty acylated proteins using omega- alkynyl-fatty acids and click chemistry. J Lipid Res. 51(6):1566-80 (*co-first authors) PMID:20028662 
  • Martin, D.D.O., Vilas, G.L., Prescher, J.A., Rajaiah, G., Falck, J.R., Bertozzi, C.R., Berthiaume, L.G. (2008) Rapid detection, discovery and identification of post-translationally myristoylated proteins during apoptosis using a bioorthogonal azidomyristate analogue. FASEB J. 22(3):797-806 PMID: 17932026