Monday, June 18, 2018

Another Disappointment as AstraZeneca and Eli Lilly Pharmaceutical Companies Discontinue Trails for Alzheimer's Drug

The fight to find a cure has hit another roadblock this week as pharmaceutical companies AstraZeneca and Eli Lilly announced that they were discontinuing their phase three trials for an experimental drug. People with early-stage Alzheimer’s disease were given lanabecestat at 20mg, 50 mg, or a placebo to assess the drug’s effects. Lanabecestat is an experimental BACE inhibitor that is being called off after the data monitoring committee saw that the drug was unlikely to meet primary endpoints.

Monday, June 18, 2018

Spread of Aggregated Protein in Alzheimer's Disease Linked to Exosomes

Although traditionally thought as the waste disposal units of the cell, exosomes have a much more complex relationship with the processing of information between cells as well. Researchers out of Linköping University have found that exosomes are spreading amyloid proteins to unaffected neurons in patients with Alzheimer’s disease. The spread of the disease has alluded researchers, as it was assumed that it was passed through proximity. Absorption of exosomes in unaffected neurons offers the answer to why spread of the disease can be observed in other parts of the brain.

Monday, June 18, 2018

High Blood Pressure Associated with Dementia Risk

Another reason to watch your blood pressure has been looked at by researchers out of the Regional Excellence Hypertension Center of the Italian Society of Hypertension in the Department of Angiocardioneurology and Translational Medicine of the I.R.C.C.S, Neuromed. Researchers asked people ages 40 to 65 with no prior symptoms or diagnosis of dementia to screen for their hypertensive status and organ damage. An MRI was utilized to determine the presence of microstructural damage in white matter of participants in relation to hypertensive status.

Monday, June 11, 2018

The Effects of Alcohol on Our Genes

Research out of the University of Illinois in Chicago examined how genes affected by alcohol and inflammation influence the development of Alzheimer’s disease. These genes are responsible for clearing amyloid beta from the brain, when affected by alcohol the ability to clear amyloid decreases and amyloid forms plaques in the brain contributing to neuronal damage. There has been a lot of research surrounding dementia and the effects of alcohol, however, this study focuses on the direct impact of alcohol on the genes that protect against dementia.

Monday, June 11, 2018

Advancing Technology Leading to Advancements in Care

This new innovative technology could help people living with dementia live independently and in their own home longer. The study is known as Technology Integrated Health Management for dementia and uses a network of internet devices such as sensors monitors and trackers. These devices are installed in the homes and can be used to detect immediate crisis, change in people’s health and changes in their daily routine. The devices are used to monitor changes that could indicate potential health issues, aiding in early detection to prevent later hospitalization.

Monday, June 11, 2018

Communication Pattern Adaptations for People Living with Dementia

Researchers out of Kumamoto University in Japan have recently mapped out communication patterns in people living with dementia. They found that often people with dementia communicate as if they have not forgotten or know exactly what is happening when they do no, as a way to “save face”, or academically referred to as  “saving appearance responses”. The researchers looked at four different types of dementia – Alzheimer’s disease, Alzheimer’s disease with cerebrovascular disease, Lewy body dementia, and mild cognitive impairment (MCI).

Monday, June 4, 2018

Comprehensive Study of APOE Gene to Understand its Role in Dementia

As a known risk factor for late-onset dementia, the APOE4 gene has been the subject of many investigations. This study, however, comprehensively dissected why the APOE4 gene was the variant that had the most risk. APOE exists in three forms, APOE 2, 3, or 4, with APOE4 being the gene which expresses the most amyloid proteins, a key component of Alzheimer’s disease. Using human stem cells, the researchers at MIT created neurons, astrocytes, and microglia cells.  They found that cells expressing APOE4 and APOE3 differed significantly in other genes, which also changes the cell behaviour.

Monday, June 4, 2018

Research from Montreal Investigates Gene BMI1 and Alzheimer's Disease

After 10 years of hard work researchers from Montreal are happy to report their findings on the most common form of Alzheimer’s disease (AD). Dr. Bernier and his research team investigated the role of the gene, BMI1 and it’s role in the development of AD. Dr. Bernier’s team determined that without a functioning BMI1 gene there is accelerated ageing of the brain, leading to the development of AD and other related conditions. The researchers looked at brains of people with AD and compared them to those who did not have AD.

Monday, June 4, 2018

Human Evolution: Changing the Brain for Better of For Worse?

New research suggests that an evolutionary adaptation in the brain may contribute to the development of Alzheimer’s disease and other related diseases. The theory stems from George Williams theory proposed in 1957, which states adaptations that made human more fit in their early years may make them more vulnerable to disease in post-reproductive years. Han Liang from the University of Texas MD Anderson Cancer Center has been doing research to test this theory, specifically how it relates to Alzheimer’s disease. The researchers examined enhancers in the body.

Monday, May 28, 2018

Recommendations for Alzheimer's Disease Therapy Development Announced at NIH Summit

At the National Institutes of Health’s Summit a collaboration of professional, government, and academic organizations came together to inform recommendations for the pursuit of Alzheimer’s disease therapy. The recommendations goal is to guide a multidisciplinary approach to research to allow different fields to coordinate efforts and skills sets in order to accelerate and mobilize research. A key theme is to address the underlying processes of the disease through the therapy and to address symptoms. Dr.

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