Alzheimer's Disease Pathology Expressed in Cardiovascular System in Female Mice

Monday, March 26, 2018

Research out of the Institute for Neuroscience at the Universitat Autonoma de Barcelona have delved into how Alzheimer’s disease is expressed in other body systems other than the brain. This research has identified that the cardiovascular system seems to alter in female mice who are of advanced age and have Alzheimer’s disease. The small blood vessels of these mice are seen to have substantial changes, which alter the ability to deliver nutrients to organs and tissues and change blood pressure. It also specifies that the determining factor is sex, which suggests women with Alzheimer’s disease are more likely to experience cardiovascular problems. Dr. Francesc Jimenez-Altayo illustrates the importance of this research by highlighting that “vascular disease resulting from oxidative stress and inflammation is an emerging concept in the study of Alzheimer's disease which is gaining clinical interest, given that subsequent cardiovascular insufficiency can alter the blood flow distribution to different organs and tissues, including the brain, which can worsen a pathology related to this type of dementia.” Essentially, the pathology of Alzheimer’s disease in the cardiovascular system exasperates the disease and has important clinical implications.

SOURCE: Science Daily, March 16, 2018 https://www.sciencedaily.com/releases/2018/03/180316111407.htm

DATE Retrieved: March 20, 2018

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