A study conducted in Sweden of 191 women ages 38 to 60 found that those with higher stamina or cardiovascular fitness were at an 88% lower risk of developing dementia than those who are moderately fit. The women completed an ergometer cycling test to measure work capacity, in which more and more resistance is added until the test is interrupted (fatigue was reached). Some individuals were unable to complete this and interrupted their test at submax levels. The study was composed of 59 “low fitness”, 92 “medium fitness” and 40 “high fitness” participants.
Researchers from the University of Regina are working to develop cameras that can detect pain for use in long-term care homes. As many residents in long-term care homes have dementia or are non-verbal, they may not be able to articulate when they are in pain. This causes pain and the underlying cause to go undetected, which reduces quality of life and can often lead to aggression or agitation. In addition, the aggression is treated with psychotropic medications, which can mask pain and increase risk of death by falls or stroke.
The Canadian federal government and Brain Canada have partnered to fund a $10.17 million grant and establish the Canadian Open Neuroscience Platform (CONP). This platform will be a large database for neuroscience research, including brain imaging, behavioral studies and genetic studies. This will allow Canadian researchers faster access to data and the ability to easily share research with other scholars. Ultimately, CONP was created to enhance research on neurological disorders, including, but not limited to; multiple sclerosis, Parkinson’s, dementia, stroke, and schizophrenia.
A study from Brazil suggests that Alzheimer’s disease (AD) may have origins in neurodevelopment. The study looked at two cohorts of children ages 6 to 14, and found that a genetic risk of Alzheimer’s was associated with lower memory performance in these children. The researchers out of Universidade Federal do Rio Grande do Sul, express that polygenic risk score for AD and memory decline and lower hippocampal volume is shown in numerous studies in adults but has not been previously explored in children.
Medical News Today reports the findings of two studies that identify the role of microglial cells (immune cells of the central nervous system) as potential avenues to prevent or reduce the protein build up telltale of Alzheimer’s disease. Out of the Neuroscience Initiative at the Sanford Burnham Prebys Medical Research Institute, researchers explored the TREM2 receptor found on microglial cells and its potential role in reducing amyloid beta buildup.