Aspirin has long been used as a pain reliever as well as a treatment for cardiovascular diseases. Now studies are linking the drug to reduced pathology for Alzheimer’s disease. In mice models, low doses of aspirin were found to reduce amyloid plaques through activating lysosomes. Research found that aspirin upregulated Transcription factor EB (TFEB), which plays a large role in regulating the creation of lysosomes. Aspirin was also found to activate peroxisome proliferator-activated receptor alpha (PPARa) which stimulates TFEB. This offers a better understanding of the pathway in which aspirin can work to treat Alzheimer’s disease.
SOURCE: Science Daily; July 2, 2018; https://www.sciencedaily.com/releases/2018/07/180702170907.htm
DATE RETRIEVED: July 6, 2018