The assumption that dying nerve cells release Tau protein is being challenged by new research out of
Washington University. Using mass spectrometry and stable isotope labelling kinetics, tau proteins were analyzed in cerebrospinal fluid of people with Alzheimer’s disease and controls. They found that certain types of Tau had faster turnover rates, which suggest biological activity. Chihiro Sato, a first author on the paper explains, “we've known for a long time that CSF tau is increased in Alzheimer's disease, but until this study, we didn't know if tau production was increased or if clearance was decreased.” They also found truncated tau in both healthy people and people with Alzheimer’s disease, which suggests that tau is actively processed. These findings allow a better understanding of tau pathology and gives a new avenue of distinguishing dementias and tauopathies.
SOURCE: Science Daily, March 21, 2018 https://www.sciencedaily.com/releases/2018/03/180321121613.htm
DATE Retrieved: March 23, 2018