Research out of the University of Illinois in Chicago examined how genes affected by alcohol and inflammation influence the development of Alzheimer’s disease. These genes are responsible for clearing amyloid beta from the brain, when affected by alcohol the ability to clear amyloid decreases and amyloid forms plaques in the brain contributing to neuronal damage. There has been a lot of research surrounding dementia and the effects of alcohol, however, this study focuses on the direct impact of alcohol on the genes that protect against dementia. After exposing cells to alcohol to examined the impact of alcohol exposure on the ability of the cell to engulf and clear amyloid beta. The levels of alcohol the cells were exposed to is compatible to the levels found in people who binge drink or are heavy drinkers. The study found that there was significant effects in the suppression of phagocytosis, engulfing and clearing, within one hour of alcohol consumption. The researchers did not continue the study to determine the effects of longer exposure to alcohol, but they determined these changes are significant enough to be a contributing factor to the development of dementia.
SOURCE: LabManager: http://www.labmanager.com/news/2018/06/how-does-alcohol-influence-the-development-of-alzheimer-s-disease-#.Wxqgmu4vy70
DATE RETRIEVED: June 8, 2018