Endosome pH Could be Used to Treat Alzheimer's Disease

Tuesday, August 7, 2018

Research out of John Hopkins Medicine suggests that one of the mechanisms in the development of Alzheimer’s disease is a pH imbalance in endosomes. When amyloid plaques cannot be cleared from the brain, the build-up creates Alzheimer’s disease. Previous studies identified that endosomes are more numerous in brains likely to develop Alzheimer’s disease. Endosomes use chaperone proteins to assist in shuttling cargo, but the process is dependent on pH levels. When the pH is too acidic, the endosomes are stuck deep in the cell, whereas if they are too basic, the endosomes are stuck at the surface. The researchers gave mice who were experiencing a pH imbalance a drug called histone deacetylase inhibitors which reversed the imbalance. This also improved amyloid plaque clearance. These inhibitors are approved for cancer treatments but more studies need to assess their effectiveness at crossing the blood-brain barrier and safety on humans.
SOURCE: Science Daily, August 2, 2018; https://www.sciencedaily.com/releases/2018/08/180802130758.htm
DATE RETRIEVED: August 7, 2018

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