Researchers from the National Institute on Aging presented in a study on mice the potential benefits of nicotinamide riboside (NR), a form of the vitamin B3 supplement, for protecting against Alzheimer’s disease and cognitive decline. Utilizing genetically modified mice to exhibit traditional Alzheimer’s pathology (such as the presence of tau and amyloid beta proteins), the researchers tested the effect the NR supplement had on their cognitive abilities and brain pathology. NR’s role in the brain is to assist in DNA repair and stem cell self-renewal by regulating levels of nicotinamide adenine dinucleotide. After feeding NR to the mice in their drinking water, the researchers found that the supplement promoted higher neuroplasticity, reduced tau proteins, and they performed better than control mice in cognitive tests. Benefits were also exhibited in physical elements, such as increased grip strength and higher endurance. These results are attributed to the NR’s ability to stimulate stem cells in muscle and brain tissue. The findings are exciting and justify further investigation in human studies to further understand the implications for people living with dementia.
Date Retrieved: February 9th 2018