Gene with Alzheimer's Disease Implications Involved in Childhood Cognition

Monday, August 14, 2017

Genetic predisposition is one of many factors implicated in developing Alzheimer’s disease. Amyloid precursor protein (APP) generates amyloid beta peptides; a mutation in the gene that encodes APP can cause these peptides to build up in plaques in the brain, which affects cognition. It is the ARC gene complex, which is involved in neural plasticity, or the brain changing and adapting over time, that contains the gene that encodes APP. Norwegian Researchers analyzed the IQ and genetic markers of over 5 thousand children, as well as the genetic markers of almost 55 thousand adults with and without Alzheimer’s disease. For the first time, this study showed a correlation between the ARC complex variation and children’s IQ’s – specifically intelligence related to problem-solving as opposed to learning and memorizing. As these findings are purely correlational and do not suggest causation, the researchers suggest that “follow-up studies are needed to more precisely determine how variants in APP may exert their effects on cognitive function over a lifespan. Such studies may have valuable implications for our understanding of etiology and, eventually, treatment of disorders associated with cognitive dysfunction, such as [Alzheimer's disease].”

SOURCE: Medical News Today: http://www.medicalnewstoday.com/articles/318809.php

ORIGINAL ARTICLE: IOS Press: http://content.iospress.com/articles/journal-of-alzheimers-disease/jad170049?resultNumber=1&totalResults=5&start=0&q=Zayats&resultsPageSize=10&rows=10

DATE RETRIEVED: August 10, 2017

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