Betanin, a substance found in beet extract, is the subject presented on at the 225th National Meeting and Exposition of the American Chemical Society. Researchers suggest that this compound acts as an inhibitor to stop the progression of Alzheimer’s disease. Previously, beet juice has shown to improve cognition and increase oxygen to the brain. With this in mind, researchers decided to investigate whether betanin prevents the misfolding of peptides and neuronal oxidation. In an experiment 3,5 di-twer-butylcatechol (DTBC), a tracking compound for oxidation, was evaluated when exposed to beta-amyloid, beta- amyloid bound to copper, and copper bound beta-amyloid with betanin. They found that beta-amyloid on its own caused no oxidation, but that beta-amyloid bound to copper experienced significant oxidation, as expected. However, the copper bound beta-amyloid with betanin experienced a reduced rate of oxidation- nearly 90%! This suggests that the compound found in beets suppress the misfolding of peptides. Dr. Li-June Ming believes that although it is a first step, the findings “will encourage other scientists to look for structures similar to betanin that could be used to synthesize drugs that could make life a bit easier for those who suffer from [Alzheimer’s] disease”.
SOURCE: Science Daily, March 20, 2018, https://www.sciencedaily.com/releases/2018/03/180320084414.htm
DATE Retrieved: March 21, 2018