Mutation in Mice Reduces the Formation of Amyloid-Beta Plaques

Tuesday, May 22, 2018

Researchers at the RIKEN Center for Brain Science have found a mutation in mice that has the potential to protect against Alzheimer’s disease. They found that this mutation can reduce the accumulation of amyloid-beta peptides. These amyloid-beta plaques are a hallmark sign of Alzheimer’s disease, created from the leftover part of the amyloid precursor protein (APP). They successfully recreated the APP gene mutation in mouse models for the purpose of the study. Previous research has shown that the deletion of the APP gene may reduce amyloid-beta plaques. This phenomenon was also observed with the mutated gene in the mouse model. The researchers had many different mouse models, each with a different degree of deletion of the APP gene. The research showed that greater deletion of the APP gene correlated with lower levels of amyloid-beta. This study shows that gene editing could have potential treatment options for Alzheimer disease with further research. Additionally, searching for beneficial mutations can lead to powerful discovery.
SOURCE: Technology Networks: https://www.technologynetworks.com/tn/news/mouse-mutation-protects-against-alzheimers-303031
DATE RETRIEVED: May 17, 2018

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