A study from Brazil suggests that Alzheimer’s disease (AD) may have origins in neurodevelopment. The study looked at two cohorts of children ages 6 to 14, and found that a genetic risk of Alzheimer’s was associated with lower memory performance in these children. The researchers out of Universidade Federal do Rio Grande do Sul, express that polygenic risk score for AD and memory decline and lower hippocampal volume is shown in numerous studies in adults but has not been previously explored in children. The sample of children also exemplified previous findings, but did not show to be driven by the APOE gene. They suggest that the presence of an APOE gene does not necessarily express itself until later years. These findings were not replicated in a Canadian cohort, however. It is cautioned by the director of the Center for Cognitive Neurology, Thomas Wisniewski, that it is much more likely to be associated with cognitive reserve than neurodevelopment.
SOURCE: Medscape, March 9, 2018; https://www.medscape.com/viewarticle/893691
AUTHOR: Megan Brooks
DATE Retrieved: March 9, 2018