Analysis of polyvinyl alcohol release from commercially available daily disposable contact lenses using an in vitro eye model

TitleAnalysis of polyvinyl alcohol release from commercially available daily disposable contact lenses using an in vitro eye model
Publication TypeJournal Article
Year of Publication2019
AuthorsPhan, C., H. Walther, D. Riederer, C. Lau, K O. K. O. Lorenz, L. Subbaraman, and L. Jones
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume107
Pagination1662-1668
KeywordsArtificial tears, Biomaterials, Biomedical engineering, Biomedical material, Contact lenses, Disposable contact lens, Hydrogel contact lens, Hydrogels, Poly (vinyl alcohol) (PVA), polyvinyl alcohol, Polyvinyl alcohols, PVA, release, Statistical significance, uptake
Abstract

The purpose of this work was to determine the release of polyvinyl alcohol (PVA) from etafilcon A, omafilcon A, and nelfilcon A daily disposable hydrogel contact lenses using a novel in vitro model. PVA is an ocular lubricant that can be found in multiple formulations of artificial tears. Nelfilcon A innately contains PVA, so only the release of PVA from this lens was evaluated. Etafilcon A and omafilcon A lenses were incubated in a PBS solution containing PVA. The release of PVA was evaluated using a novel in vitro blink platform with Milli-Q water and PBS under various blink conditions and flow rates. Nelfilcon A lenses significantly released more PVA than other lenses at 0.5 and 1.5 h in both PBS and Milli-Q water (p 0.05). All tested groups and lenses showed a burst release within the first 4.5 h and rapidly plateaued thereafter. The current study demonstrates that releasable PVA (whether through uptake or through being inherently available from the material) is loosely bound on hydrogel lenses, and the majority is released within 4.5 h. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1662–1668, 2019. © 2018 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc.

DOI10.1002/jbm.b.34259