Caffeine increases the velocity of rapid eye movements in unfatigued humans

TitleCaffeine increases the velocity of rapid eye movements in unfatigued humans
Publication TypeJournal Article
Year of Publication2017
AuthorsConnell, C., B. Thompson, J. Turuwhenua, R. Hess, and N. Gant
JournalPsychopharmacology
Volume234
Pagination2311-2323
Keywordsadult, Article, body mass, Caffeine, catecholamine, Central Nervous System Stimulants, central stimulant agent, controlled study, Cross-Over Studies, crossover procedure, double blind procedure, Double-Blind Method, drug effects, eye movement, eye movement control, Eye Movements, fatigue, female, human, human experiment, Humans, infrared oculography, kinematics, male, normal human, Oculomotor control, Optokinetic nystagmus, orientation, physiology, priority journal, Pursuit, randomized controlled trial, REM sleep, Saccades, saccadic eye movement, Smooth, Smooth pursuit, smooth pursuit eye movement, stimulus response, task performance, velocity, Vision, Visual Perception, young adult
Abstract

Background: Caffeine is a widely used dietary stimulant that can reverse the effects of fatigue on cognitive, motor and oculomotor function. However, few studies have examined the effect of caffeine on the oculomotor system when homeostasis has not been disrupted by physical fatigue. This study examined the influence of a moderate dose of caffeine on oculomotor control and visual perception in participants who were not fatigued. Methods: Within a placebo-controlled crossover design, 13 healthy adults ingested caffeine (5 mg·kg−1 body mass) and were tested over 3 h. Eye movements, including saccades, smooth pursuit and optokinetic nystagmus, were measured using infrared oculography. Results: Caffeine was associated with higher peak saccade velocities (472 ± 60° s−1) compared to placebo (455 ± 62° s−1). Quick phases of optokinetic nystagmus were also significantly faster with caffeine, whereas pursuit eye movements were unchanged. Non-oculomotor perceptual tasks (global motion and global orientation processing) were unaffected by caffeine. Conclusions: These results show that oculomotor control is modulated by a moderate dose of caffeine in unfatigued humans. These effects are detectable in the kinematics of rapid eye movements, whereas pursuit eye movements and visual perception are unaffected. Oculomotor functions may be sensitive to changes in central catecholamines mediated via caffeine’s action as an adenosine antagonist, even when participants are not fatigued. © 2017, Springer-Verlag Berlin Heidelberg.

DOI10.1007/s00213-017-4638-1