Comparison of non-invasive tear film stability measurement techniques

TitleComparison of non-invasive tear film stability measurement techniques
Publication TypeJournal Article
Year of Publication2018
AuthorsWang, M. T. M., P. J. Murphy, K. J. Blades, and J. P. Craig
JournalClinical and Experimental Optometry
Keywordsadult, break-up time, chemistry, clinical article, controlled clinical trial, controlled study, Cornea, Cross-Over Studies, crossover procedure, female, human, Humans, instrument validation, interferometry, keratoscopy, lacrimal fluid, male, metabolism, non invasive procedure, non-invasive techniques, procedures, Prospective Studies, prospective study, randomized controlled trial, reference value, Reference Values, single blind procedure, Single-Blind Method, tear film, tear film stability, Tears, white light
AbstractBackground: Measurement of tear film stability is commonly used to give an indication of tear film quality but a number of non-invasive techniques exists within the clinical setting. This study sought to compare three non-invasive tear film stability measurement techniques: instrument-mounted wide-field white light clinical interferometry, instrument-mounted keratoscopy and hand-held keratoscopy. Methods: Twenty-two subjects were recruited in a prospective, randomised, masked, cross-over study. Tear film break-up or thinning time was measured non-invasively by independent experienced examiners, with each of the three devices, in a randomised order, within an hour. Results: Significant correlation was observed between instrument-mounted interferometric and keratoscopic measurements (p 0.05). Tear film stability values obtained from the hand-held device were significantly shorter and demonstrated narrower spread than the other two instruments (all p 0.05). Conclusion: Good clinical agreement exists between the instrument-mounted interferometric and keratoscopic measurements but not between the hand-held device and either of the instrument-mounted techniques. The results highlight the importance of specifying the instrument employed to record non-invasive tear film stability. © 2017 Optometry Australia