Contrast-balanced binocular treatment in children with deprivation amblyopia

TitleContrast-balanced binocular treatment in children with deprivation amblyopia
Publication TypeJournal Article
Year of Publication2018
AuthorsHamm, L., Z. Chen, J. Li, S. Dai, J. Black, J. Yuan, M. Yu, and B. Thompson
JournalClinical and Experimental Optometry
Keywordsadolescent, Amblyopia, Binocular, binocular treatment, binocular vision, cataract, cataract extraction, child, complication, Contrast sensitivity, deprivation amblyopia, Eyeglasses, follow up, Follow-Up Studies, human, Humans, Infant, Intraocular, lens implantation, paediatric cataracts, pathophysiology, physiology, Preschool, preschool child, Prospective Studies, prospective study, pseudophakia, sensory deprivation, spectacles, Vision, Visual acuity

{Background: Children with deprivation amblyopia due to childhood cataract have been excluded from much of the emerging research into amblyopia treatment. An investigation was conducted to determine whether contrast-balanced binocular treatment – a strategy currently being explored for children with anisometropic and strabismic amblyopia – may be effective in children with deprivation amblyopia. Methods: An unmasked, case-series design intended to assess proof of principle was employed. Eighteen children with deprivation amblyopia due to childhood cataracts (early bilateral n = 7, early unilateral n = 7, developmental n = 4), as well as 10 children with anisometropic (n = 8) or mixed anisometropic and strabismic amblyopia (n = 2) were prescribed one hour a day of treatment over a six-week period. Supervised treatment was available. Visual acuity, contrast sensitivity, global motion perception and interocular suppression were measured pre- and post-treatment. Results: Visual acuity improvements occurred in the anisometropic/strabismic group (0.15 ± 0.05 logMAR