Efficacy of Contact Lens Care Solutions in Removing Cholesterol Deposits from Silicone Hydrogel Contact Lenses

TitleEfficacy of Contact Lens Care Solutions in Removing Cholesterol Deposits from Silicone Hydrogel Contact Lenses
Publication TypeJournal Article
Year of Publication2019
AuthorsWalther, H., L. Subbaraman, and L. Jones
JournalEye and Contact Lens
KeywordsCholesterol, Cleaning, contact lens solution, Contact Lens Solutions, Contact lenses, human, Humans, Hydrophilic, hydrophilic contact lens, Lipid deposition, Multipurpose solution, silicone derivative, silicone hydrogel, Silicones

Purpose:To determine the efficacy of multipurpose solutions (MPSs) on the removal of cholesterol deposits from silicone hydrogel (SH) contact lens materials using an in vitro model.Materials and Methods:Five SH lens materials: senofilcon A, comfilcon A, balafilcon A, lotrafilcon A, and lotrafilcon B were removed from the blister pack (n=4 for each lens type), incubated for 7 days at 37°C in an artificial tear solution containing 14 C radiolabeled cholesterol. Thereafter, lenses were stored in a preserved saline solution control (Sensitive Eyes Saline Plus) or cleaned with 1 of the 5 MPSs incorporating different preservatives (POLYQUAD/ALDOX, polyquaternium-1/alexidine, polyquaternium-1/PHMB, and 2 based on PHMB alone) using a rub and rinse technique, according to the manufacturer's recommendations, and stored in the MPS for a minimum of 6 hr. Lenses were then extracted with 2:1 chloroform:methanol, analyzed in a beta counter, and g/lens of cholesterol was determined.Results:Balafilcon A and senofilcon A lens materials showed the highest amounts of accumulated cholesterol (0.93±0.02 g/lens; 0.95±0.01 g/lens, respectively), whereas lotrafilcon A and lotrafilcon B deposited the lowest amounts (0.37±0.03 g/lens; 0.47±0.12 g/lens, respectively). For all lens materials, the MPS preserved with POLYQUAD/ALDOX removed more deposited cholesterol than any other test solution; however, the amount of removed cholesterol contamination from the individual contact lenses was only statistically significant for balafilcon A and senofilcon A (P=0.006 and P=0.042, respectively). Sensitive eyes and the other evaluated MPSs showed no significant effect on cholesterol removal (P>0.05).Conclusion:Cholesterol-removal efficacy varies depending on the combination of lens material and solution. Only 1 MPS showed a statistically significant reduction of cholesterol deposit for only 2 of the 5 tested lens materials. © 2018 Contact Lens Association of Ophthalmologists, Inc.